A robust biostatistical method leverages informative but uncertainly determined qPCR data for biomarker detection, early diagnosis, and treatment

• Wei Zhuang ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: Wei.Zhuang@fda.hhs.gov

  Affiliation Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, United States of America

  https://orcid.org/0000-0002-9998-4753

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• Luísa Camacho,

  Roles Conceptualization, Investigation, Methodology, Resources, Writing – review & editing

  Affiliation Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, United States of America

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• Camila S. Silva,

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, United States of America

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• Michael Thomson,

  Roles Writing – review & editing

  Affiliation Office of New Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, United States of America

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• Kevin Snyder

  Roles Investigation, Visualization, Writing – review & editing

  Affiliation Office of New Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, United States of America

  https://orcid.org/0000-0003-3029-4815

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