Microglia-secreted TNF-α affects differentiation efficiency and viability of pluripotent stem cell-derived human dopaminergic precursors

Shirley D. Wenker; María Isabel Farias; Victoria Gradaschi; Corina Garcia; Juan Beauquis; María Celeste Leal; Carina Ferrari; Xianmin Zeng; Fernando J. Pitossi

doi:10.1371/journal.pone.0263021

Loading metrics

Open Access

Peer-reviewed

Research Article

Microglia-secreted TNF-α affects differentiation efficiency and viability of pluripotent stem cell-derived human dopaminergic precursors

Shirley D. Wenker,

Roles Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing

Affiliation Fundación Instituto Leloir—IIBBA-CONICET, Buenos Aires, Argentina

https://orcid.org/0000-0001-6940-4757

⨯
María Isabel Farias,

Roles Investigation, Methodology

Affiliation Fundación Instituto Leloir—IIBBA-CONICET, Buenos Aires, Argentina
⨯
Victoria Gradaschi,

Roles Investigation, Methodology

Current address: Facultad de Ciencias Exactas y Naturales, Departamento de Química Biológica, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina

Affiliation Fundación Instituto Leloir—IIBBA-CONICET, Buenos Aires, Argentina
⨯
Corina Garcia,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Fundación Instituto Leloir—IIBBA-CONICET, Buenos Aires, Argentina
⨯
Juan Beauquis,

Roles Investigation, Methodology

Affiliations Instituto de Biología y Medicina Experimental, CONICET, Buenos Aires, Argentina; Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina, Universidad de Buenos Aires, Buenos Aires, Argentina
⨯
María Celeste Leal,

Roles Conceptualization, Investigation, Methodology, Writing – review & editing

Affiliation Fundación Instituto Leloir—IIBBA-CONICET, Buenos Aires, Argentina
⨯
Carina Ferrari,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Fundación Instituto Leloir—IIBBA-CONICET, Buenos Aires, Argentina
⨯
Xianmin Zeng,

Roles Resources

Affiliation RxCell, Novato, CA, United States of America
⨯
Fernando J. Pitossi

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Writing – original draft, Writing – review & editing

* E-mail: fpitossi@leloir.org.ar

Affiliation Fundación Instituto Leloir—IIBBA-CONICET, Buenos Aires, Argentina
⨯

Microglia-secreted TNF-α affects differentiation efficiency and viability of pluripotent stem cell-derived human dopaminergic precursors

Shirley D. Wenker,
María Isabel Farias,
Victoria Gradaschi,
Corina Garcia,
Juan Beauquis,
María Celeste Leal,
Carina Ferrari,
Xianmin Zeng,
Fernando J. Pitossi

Published: September 26, 2023
https://doi.org/10.1371/journal.pone.0263021

Reader Comments (1)

Post a new comment on this article

0 Responses

09 Oct 2023
13:11 GMT
Most Recent

alterations Posted by fpitossi on 09 Oct 2023 at 13:11 GMT

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Microglial cells
Is the Subject Area "Microglial cells" applicable to this article?

Thanks for your feedback.
Cell differentiation
Is the Subject Area "Cell differentiation" applicable to this article?

Thanks for your feedback.
Precursor cells
Is the Subject Area "Precursor cells" applicable to this article?

Thanks for your feedback.
Neurites
Is the Subject Area "Neurites" applicable to this article?

Thanks for your feedback.
Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Immunofluorescence
Is the Subject Area "Immunofluorescence" applicable to this article?

Thanks for your feedback.
Dopaminergics
Is the Subject Area "Dopaminergics" applicable to this article?

Thanks for your feedback.
Neuronal differentiation
Is the Subject Area "Neuronal differentiation" applicable to this article?

Thanks for your feedback.