Intravenous administration of human mesenchymal stem cells derived from adipose tissue and umbilical cord improves neuropathic pain via suppression of neuronal damage and anti-inflammatory actions in rats

• Kanako Miyano ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Writing – original draft

  * E-mail: k.miyano@jikei.ac.jp

  Affiliation Department of Pain Control Research, The Jikei University School of Medicine, Nishishimbashi, Minato-ku, Tokyo, Japan

  https://orcid.org/0000-0003-1673-6074

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• Minori Ikehata,

  Roles Investigation, Methodology

  Affiliation R&D Department, Biomimetics Sympathies Inc., Aomi, Koto-ku, Tokyo, Japan

  ⨯
• Kaori Ohshima,

  Roles Investigation

  Affiliations Department of Pain Control Research, The Jikei University School of Medicine, Nishishimbashi, Minato-ku, Tokyo, Japan, Pathology, Immunology and Microbiology, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan

  ⨯
• Yuki Yoshida,

  Roles Investigation

  Affiliation Laboratory of Molecular Pathology and Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Yamazaki, Noda, Chiba, Japan

  ⨯
• Yasuhiro Nose,

  Roles Investigation

  Affiliation R&D Department, Biomimetics Sympathies Inc., Aomi, Koto-ku, Tokyo, Japan

  ⨯
• Sei-ichi Yoshihara,

  Roles Investigation

  Affiliation R&D Department, Biomimetics Sympathies Inc., Aomi, Koto-ku, Tokyo, Japan

  ⨯
• Katsuyuki Oki,

  Roles Conceptualization

  Affiliation R&D Department, Biomimetics Sympathies Inc., Aomi, Koto-ku, Tokyo, Japan

  ⨯
• Seiji Shiraishi,

  Roles Conceptualization, Data curation, Methodology

  Affiliation Division of Cancer Pathophysiology, National Hospital Organization Kure Medical, Kure, Hiroshima, Japan

  ⨯
• Miaki Uzu,

  Roles Formal analysis

  Affiliation Vitrigel Project, Institute of Agrobiological Sciences, National Agriculture and Food Research Organization, Tsukuba, Ibaraki, Japan

  ⨯
• Miki Nonaka,

  Roles Formal analysis

  Affiliation Department of Pain Control Research, The Jikei University School of Medicine, Nishishimbashi, Minato-ku, Tokyo, Japan

  ⨯
• Yoshikazu Higami,

  Roles Resources

  Affiliation Laboratory of Molecular Pathology and Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Yamazaki, Noda, Chiba, Japan

  ⨯
• Yasuhito Uezono

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

  Affiliation Department of Pain Control Research, The Jikei University School of Medicine, Nishishimbashi, Minato-ku, Tokyo, Japan

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