RNA reference materials with defined viral RNA loads of SARS-CoV-2—A useful tool towards a better PCR assay harmonization

• Laura Vierbaum ,

  Contributed equally to this work with: Laura Vierbaum, Nathalie Wojtalewicz, Martin Kammel

  Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation INSTAND e.V., Society for Promoting Quality Assurance in Medical Laboratories, Duesseldorf, North Rhine-Westphalia, Germany

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• Nathalie Wojtalewicz ,

  Contributed equally to this work with: Laura Vierbaum, Nathalie Wojtalewicz, Martin Kammel

  Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation INSTAND e.V., Society for Promoting Quality Assurance in Medical Laboratories, Duesseldorf, North Rhine-Westphalia, Germany

  https://orcid.org/0000-0002-1977-7931

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• Hans-Peter Grunert,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Resources, Validation, Writing – review & editing

  Affiliation GBD Gesellschaft fuer Biotechnologische Diagnostik mbH, Berlin, Germany

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• Vanessa Lindig,

  Roles Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – review & editing

  Affiliation IQVD GmbH, Institut fuer Qualitaetssicherung in der Virusdiagnostik, Berlin, Germany

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• Ulf Duehring,

  Roles Formal analysis, Investigation, Resources, Validation

  Affiliation GBD Gesellschaft fuer Biotechnologische Diagnostik mbH, Berlin, Germany

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• Christian Drosten,

  Roles Conceptualization, Investigation, Methodology, Resources

  Affiliation Institute of Virology, Charité - University Medicine Berlin; National Consultant Laboratory for Coronaviruses; German Centre for Infection Research, Berlin, Germany

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• Victor Corman,

  Roles Conceptualization, Investigation, Methodology, Resources, Validation, Writing – review & editing

  Affiliation Institute of Virology, Charité - University Medicine Berlin; National Consultant Laboratory for Coronaviruses; German Centre for Infection Research, Berlin, Germany

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• Daniela Niemeyer,

  Roles Investigation, Resources, Validation, Writing – review & editing

  Affiliation Institute of Virology, Charité - University Medicine Berlin; National Consultant Laboratory for Coronaviruses; German Centre for Infection Research, Berlin, Germany

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• Sandra Ciesek,

  Roles Investigation, Methodology, Resources

  Affiliations Institute for Medical Virology, University Hospital, Goethe University Frankfurt, Frankfurt, Hesse, Germany, German Centre for Infection Research, External partner site Frankfurt, Hesse, Germany, Fraunhofer Institute for Molecular Biology and Applied Ecology, Branch Translational Medicine and Pharmacology, Frankfurt, Hesse, Germany

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• Holger F. Rabenau,

  Roles Conceptualization, Investigation, Methodology, Resources, Validation, Writing – review & editing

  Affiliation Institute for Medical Virology, University Hospital, Goethe University Frankfurt, Frankfurt, Hesse, Germany

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• Annemarie Berger,

  Roles Investigation, Resources, Validation

  Affiliation Institute for Medical Virology, University Hospital, Goethe University Frankfurt, Frankfurt, Hesse, Germany

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• Martin Obermeier,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliation Medizinisches Infektiologiezentrum Berlin, Germany

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• Andreas Nitsche,

  Roles Conceptualization, Investigation, Methodology, Resources, Validation, Writing – review & editing

  Affiliation Robert Koch-Institute, Centre for Biological Threats and Special Pathogens, Berlin, Germany

  ⨯
• Janine Michel,

  Roles Conceptualization, Investigation, Methodology, Resources, Validation, Writing – review & editing

  Affiliation Robert Koch-Institute, Centre for Biological Threats and Special Pathogens, Berlin, Germany

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• Martin Mielke,

  Roles Conceptualization, Funding acquisition, Methodology, Writing – review & editing

  Affiliation Robert Koch-Institute, Department for Infectious Diseases, Berlin, Germany

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• Jim Huggett,

  Roles Formal analysis, Investigation, Methodology, Resources, Writing – review & editing

  Affiliations National Measurement Laboratory, LGC, Teddington, Middlesex, United Kingdom, Faculty of Health & Medical Science, School of Biosciences & Medicine, University of Surrey, Guildford, United Kingdom

  https://orcid.org/0000-0002-0945-1911

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• Denise O’Sullivan,

  Roles Formal analysis, Investigation, Resources, Writing – review & editing

  Affiliation National Measurement Laboratory, LGC, Teddington, Middlesex, United Kingdom

  ⨯
• Eloise Busby,

  Roles Investigation, Resources

  Affiliation National Measurement Laboratory, LGC, Teddington, Middlesex, United Kingdom

  ⨯
• Simon Cowen,

  Roles Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation National Measurement Laboratory, LGC, Teddington, Middlesex, United Kingdom

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• Peter M. Vallone,

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Materials Measurement Laboratory, Biomolecular Measurement Division, NIST, National Institute of Standards and Technology, Applied Genetics Group, Gaithersburg, Massachusetts, United States of America

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• Megan H. Cleveland,

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Materials Measurement Laboratory, Biomolecular Measurement Division, NIST, National Institute of Standards and Technology, Applied Genetics Group, Gaithersburg, Massachusetts, United States of America

  https://orcid.org/0000-0002-5584-9314

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• Samreen Falak,

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Physikalisch-Technische Bundesanstalt, Berlin, Germany

  https://orcid.org/0000-0002-8454-7884

  ⨯
• Andreas Kummrow,

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Physikalisch-Technische Bundesanstalt, Berlin, Germany

  ⨯
• Thomas Keller,

  Roles Formal analysis, Methodology, Validation, Writing – review & editing

  Affiliation ACOMED statistik, Leipzig, Saxony, Germany

  https://orcid.org/0000-0001-8160-3046

  ⨯
• Ingo Schellenberg,

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  Affiliations INSTAND e.V., Society for Promoting Quality Assurance in Medical Laboratories, Duesseldorf, North Rhine-Westphalia, Germany, Institute of Bioanalytical Sciences, Center of Life Sciences, Anhalt University of Applied Sciences, Bernburg, Saxony-Anhalt, Germany

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• Heinz Zeichhardt,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations INSTAND e.V., Society for Promoting Quality Assurance in Medical Laboratories, Duesseldorf, North Rhine-Westphalia, Germany, GBD Gesellschaft fuer Biotechnologische Diagnostik mbH, Berlin, Germany, IQVD GmbH, Institut fuer Qualitaetssicherung in der Virusdiagnostik, Berlin, Germany

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•  [ ... ],
• Martin Kammel

  Contributed equally to this work with: Laura Vierbaum, Nathalie Wojtalewicz, Martin Kammel

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: m.kammel@iqvd.de

  Affiliations INSTAND e.V., Society for Promoting Quality Assurance in Medical Laboratories, Duesseldorf, North Rhine-Westphalia, Germany, IQVD GmbH, Institut fuer Qualitaetssicherung in der Virusdiagnostik, Berlin, Germany

  https://orcid.org/0000-0002-2011-086X

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