Endosomal structure and APP biology are not altered in a preclinical mouse cellular model of Down syndrome

Claudia Cannavo; Karen Cleverley; Cheryl Maduro; Paige Mumford; Dale Moulding; Elizabeth M. C. Fisher; Frances K. Wiseman

doi:10.1371/journal.pone.0262558

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Open Access

Peer-reviewed

Research Article

Endosomal structure and APP biology are not altered in a preclinical mouse cellular model of Down syndrome

Claudia Cannavo,

Roles Formal analysis, Investigation, Writing – original draft

Affiliations UK Dementia Research Institute, UCL Queen Square Institute of Neurology, London, United Kingdom, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, United Kingdom
⨯
Karen Cleverley,

Roles Investigation

Affiliation Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, United Kingdom
⨯
Cheryl Maduro,

Roles Investigation

Affiliation Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, United Kingdom
⨯
Paige Mumford,

Roles Data curation, Investigation, Writing – review & editing

Affiliation UK Dementia Research Institute, UCL Queen Square Institute of Neurology, London, United Kingdom
⨯
Dale Moulding,

Roles Methodology, Resources, Software, Supervision, Writing – review & editing

Affiliation Light Microscopy Core Facility, UCL Great Ormond Street Institute of Child Health, London, United Kingdom
⨯
Elizabeth M. C. Fisher ,

Roles Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

¶Membership of the LonDownS Consortium is provided in the Acknowledgments.

Affiliation Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, United Kingdom
⨯
Frances K. Wiseman

Roles Conceptualization, Data curation, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: f.wiseman@ucl.ac.uk

¶Membership of the LonDownS Consortium is provided in the Acknowledgments.

Affiliation UK Dementia Research Institute, UCL Queen Square Institute of Neurology, London, United Kingdom

https://orcid.org/0000-0001-9323-3548

⨯

Endosomal structure and APP biology are not altered in a preclinical mouse cellular model of Down syndrome

Claudia Cannavo,
Karen Cleverley,
Cheryl Maduro,
Paige Mumford,
Dale Moulding,
Elizabeth M. C. Fisher,
Frances K. Wiseman

Published: May 11, 2022
https://doi.org/10.1371/journal.pone.0262558

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