Ongoing viral replication and production of infectious virus in patients with chronic hepatitis B virus suppressed below the limit of quantitation on long-term nucleos(t)ide therapy

Dara L Burdette; Scott Lazerwith; Jenny Yang; Henry L. Y. Chan; William E. Delaney IV; Simon P. Fletcher; Tomas Cihlar; Becket Feierbach

doi:10.1371/journal.pone.0262516

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Open Access

Peer-reviewed

Research Article

Ongoing viral replication and production of infectious virus in patients with chronic hepatitis B virus suppressed below the limit of quantitation on long-term nucleos(t)ide therapy

Dara L Burdette,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing

Current address: Tempest Therapeutics, South San Francisco, CA, United States of America

Affiliation Discovery Virology, Gilead Sciences, Foster City, CA, United States of America

https://orcid.org/0000-0003-3856-0815

⨯
Scott Lazerwith,

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation Medicinal Chemistry, Gilead Sciences, Foster City, CA, United States of America
⨯
Jenny Yang,

Roles Investigation, Writing – review & editing

Current address: Allovir, Cambridge, MA, United States of America

Affiliation Clinical Research, Gilead Sciences, Foster City, CA, United States of America
⨯
Henry L. Y. Chan,

Roles Investigation, Writing – review & editing

Affiliation The Chinese University of Hong Kong, Hong Kong SAR, China
⨯
William E. Delaney IV,

Roles Conceptualization, Methodology, Resources, Supervision, Writing – review & editing

Current address: Assembly Biosciences, San Francisco, CA, United States of America

Affiliation Discovery Virology, Gilead Sciences, Foster City, CA, United States of America
⨯
Simon P. Fletcher,

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation Discovery Virology, Gilead Sciences, Foster City, CA, United States of America
⨯
Tomas Cihlar,

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation Discovery Virology, Gilead Sciences, Foster City, CA, United States of America
⨯
Becket Feierbach

Roles Conceptualization, Resources, Supervision, Writing – review & editing

* E-mail: Becket.Feierbach@Gilead.com

Affiliation Clinical Virology, Gilead Sciences, Foster City, CA, United States of America
⨯

Ongoing viral replication and production of infectious virus in patients with chronic hepatitis B virus suppressed below the limit of quantitation on long-term nucleos(t)ide therapy

Dara L Burdette,
Scott Lazerwith,
Jenny Yang,
Henry L. Y. Chan,
William E. Delaney IV,
Simon P. Fletcher,
Tomas Cihlar,
Becket Feierbach

Published: April 1, 2022
https://doi.org/10.1371/journal.pone.0262516

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