Therapeutic treatment with the anti-inflammatory drug candidate MW151 may partially reduce memory impairment and normalizes hippocampal metabolic markers in a mouse model of comorbid amyloid and vascular pathology

David J. Braun; David K. Powell; Christopher J. McLouth; Saktimayee M. Roy; D. Martin Watterson; Linda J. Van Eldik

doi:10.1371/journal.pone.0262474

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Peer-reviewed

Research Article

Therapeutic treatment with the anti-inflammatory drug candidate MW151 may partially reduce memory impairment and normalizes hippocampal metabolic markers in a mouse model of comorbid amyloid and vascular pathology

David J. Braun,

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing

Affiliations Department of Neuroscience, University of Kentucky, Lexington, Kentucky, United States of America, Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, United States of America
⨯
David K. Powell,

Roles Investigation, Visualization, Writing – review & editing

Affiliations Department of Neuroscience, University of Kentucky, Lexington, Kentucky, United States of America, Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Christopher J. McLouth,

Roles Formal analysis, Writing – review & editing

Affiliation Department of Behavioral Science, University of Kentucky, Lexington, Kentucky, United States of America

https://orcid.org/0000-0002-5434-9748

⨯
Saktimayee M. Roy,

Roles Methodology, Resources, Writing – review & editing

Affiliation Department of Pharmacology, Northwestern University, Chicago, Illinois, United States of America
⨯
D. Martin Watterson,

Roles Funding acquisition, Methodology, Resources, Writing – review & editing

Affiliation Department of Pharmacology, Northwestern University, Chicago, Illinois, United States of America
⨯
Linda J. Van Eldik

Roles Conceptualization, Funding acquisition, Project administration, Visualization, Writing – review & editing

* E-mail: linda.vaneldik@uky.edu

Affiliations Department of Neuroscience, University of Kentucky, Lexington, Kentucky, United States of America, Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, United States of America

https://orcid.org/0000-0002-8139-6400

⨯

Therapeutic treatment with the anti-inflammatory drug candidate MW151 may partially reduce memory impairment and normalizes hippocampal metabolic markers in a mouse model of comorbid amyloid and vascular pathology

David J. Braun,
David K. Powell,
Christopher J. McLouth,
Saktimayee M. Roy,
D. Martin Watterson,
Linda J. Van Eldik

Published: January 26, 2022
https://doi.org/10.1371/journal.pone.0262474

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