In silico analysis of potential off-target sites to gene editing for Mucopolysaccharidosis type I using the CRISPR/Cas9 system: Implications for population-specific treatments

• Paola Carneiro,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Post-Graduation Program on Genetics and Molecular Biology, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil, Bioinformatics Core, Experimental Research Center, Hospital de Clínicas, Porto Alegre, Rio Grande do Sul, Brazil, Cell, Tissue and Genes Laboratory, Experimental Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil

  https://orcid.org/0000-0001-8401-3332

  ⨯
• Martiela Vaz de Freitas,

  Roles Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Post-Graduation Program on Genetics and Molecular Biology, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil, Bioinformatics Core, Experimental Research Center, Hospital de Clínicas, Porto Alegre, Rio Grande do Sul, Brazil, Cell, Tissue and Genes Laboratory, Experimental Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil

  https://orcid.org/0000-0003-4178-6604

  ⨯
• Ursula Matte

  Roles Conceptualization, Investigation, Methodology, Writing – original draft, Writing – review & editing

  * E-mail: umatte@hcpa.edu.br

  Affiliations Post-Graduation Program on Genetics and Molecular Biology, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil, Bioinformatics Core, Experimental Research Center, Hospital de Clínicas, Porto Alegre, Rio Grande do Sul, Brazil, Cell, Tissue and Genes Laboratory, Experimental Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil, Department of Genetics, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

  ⨯