A gene expression biomarker for predictive toxicology to identify chemical modulators of NF-κB

Katharine L. Korunes; Jie Liu; Ruili Huang; Menghang Xia; Keith A. Houck; J. Christopher Corton

doi:10.1371/journal.pone.0261854

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Open Access

Peer-reviewed

Research Article

A gene expression biomarker for predictive toxicology to identify chemical modulators of NF-κB

Katharine L. Korunes,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Current address: Department of Evolutionary Anthropology, Duke University, Durham, North Carolina, United States of America

Affiliations Center for Computational Toxicology and Exposure, US Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America, Biology Department, Duke University, Durham, North Carolina, United States of America

https://orcid.org/0000-0002-2648-4707

⨯
Jie Liu,

Roles Formal analysis, Investigation, Validation, Writing – review & editing

Affiliation Center for Computational Toxicology and Exposure, US Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America

https://orcid.org/0000-0002-4530-1443

⨯
Ruili Huang,

Roles Data curation, Formal analysis, Resources, Validation, Writing – review & editing

Affiliation National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, United States of America

https://orcid.org/0000-0001-8886-8311

⨯
Menghang Xia,

Roles Data curation, Formal analysis, Investigation, Resources, Writing – review & editing

Affiliation National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, United States of America

https://orcid.org/0000-0001-7285-8469

⨯
Keith A. Houck,

Roles Data curation, Formal analysis, Investigation, Resources, Writing – review & editing

Affiliation Center for Computational Toxicology and Exposure, US Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America

https://orcid.org/0000-0002-0055-2249

⨯
J. Christopher Corton

Roles Conceptualization, Data curation, Formal analysis, Investigation, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: corton.chris@epa.gov

Affiliation Center for Computational Toxicology and Exposure, US Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America

https://orcid.org/0000-0002-6197-2036

⨯

A gene expression biomarker for predictive toxicology to identify chemical modulators of NF-κB

Katharine L. Korunes,
Jie Liu,
Ruili Huang,
Menghang Xia,
Keith A. Houck,
J. Christopher Corton

Published: February 2, 2022
https://doi.org/10.1371/journal.pone.0261854

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