A PDK-1 allosteric agonist neutralizes insulin signaling derangements and beta-amyloid toxicity in neuronal cells and in vitro

• Henry Querfurth ,

  Contributed equally to this work with: Henry Querfurth, Han-Kyu Lee

  Roles Conceptualization, Data curation, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: henry.querfurth@tufts.edu

  Affiliation Department of Neurology, Tufts Medical Center, Boston, MA, United States of America

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• John Marshall,

  Roles Data curation, Resources

  Affiliation Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI, United States of America

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• Keykavous Parang,

  Roles Data curation, Resources, Writing – review & editing

  Affiliation Center for Targeted Drug Delivery, Chapman University, School of Pharmacology, Irvine, CA United States of America

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• Mengia S. Rioult-Pedotti,

  Roles Data curation

  Affiliations Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI, United States of America, Department of Neurology, Clinical Neurorehabilitation, University of Zurich, Zurich, Switzerland

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• Rakesh Tiwari,

  Roles Formal analysis, Methodology

  Affiliation Center for Targeted Drug Delivery, Chapman University, School of Pharmacology, Irvine, CA United States of America

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• Bumsup Kwon,

  Roles Data curation, Formal analysis

  Affiliation Department of Neurology, Rhode Island Hospital, Providence, RI, United States of America

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• Steve Reisinger,

  Roles Data curation, Resources, Writing – review & editing

  Affiliation Med Chem Partners, Lexington, MA, United States of America

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• Han-Kyu Lee

  Contributed equally to this work with: Henry Querfurth, Han-Kyu Lee

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliation Department of Neurology, Tufts Medical Center, Boston, MA, United States of America

  https://orcid.org/0000-0002-3787-7995

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