SARS-CoV-2 spike-specific memory B cells express higher levels of T-bet and FcRL5 after non-severe COVID-19 as compared to severe disease

Raphael A. Reyes; Kathleen Clarke; S. Jake Gonzales; Angelene M. Cantwell; Rolando Garza; Gabriel Catano; Robin E. Tragus; Thomas F. Patterson; Sebastiaan Bol; Evelien M. Bunnik

doi:10.1371/journal.pone.0261656

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Open Access

Peer-reviewed

Research Article

SARS-CoV-2 spike-specific memory B cells express higher levels of T-bet and FcRL5 after non-severe COVID-19 as compared to severe disease

Raphael A. Reyes,

Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation Department of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

https://orcid.org/0000-0002-2234-4758

⨯
Kathleen Clarke,

Roles Investigation, Writing – review & editing

Affiliation Department of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
⨯
S. Jake Gonzales,

Roles Investigation, Writing – review & editing

Affiliation Department of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

https://orcid.org/0000-0002-6621-4103

⨯
Angelene M. Cantwell,

Roles Investigation, Writing – review & editing

Affiliation Department of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

https://orcid.org/0000-0001-5122-6112

⨯
Rolando Garza,

Roles Writing – review & editing

Affiliation Department of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
⨯
Gabriel Catano,

Roles Resources

Affiliation Department of Medicine, Division of Infectious Diseases, The University of Texas Health Science Center at San Antonio, University Health System, San Antonio, Texas, United States of America

https://orcid.org/0000-0001-6047-2286

⨯
Robin E. Tragus,

Roles Resources

Affiliation Department of Medicine, Division of Infectious Diseases, The University of Texas Health Science Center at San Antonio, University Health System, San Antonio, Texas, United States of America

https://orcid.org/0000-0001-6980-9164

⨯
Thomas F. Patterson,

Roles Resources

Affiliations Department of Medicine, Division of Infectious Diseases, The University of Texas Health Science Center at San Antonio, University Health System, San Antonio, Texas, United States of America, The South Texas Veterans Health Care System, San Antonio, Texas, United States of America
⨯
Sebastiaan Bol,

Roles Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation Department of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

https://orcid.org/0000-0002-3843-6657

⨯
Evelien M. Bunnik

Roles Conceptualization, Funding acquisition, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: bunnik@uthscsa.edu

Affiliation Department of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America

https://orcid.org/0000-0003-4003-3053

⨯

SARS-CoV-2 spike-specific memory B cells express higher levels of T-bet and FcRL5 after non-severe COVID-19 as compared to severe disease

Raphael A. Reyes,
Kathleen Clarke,
S. Jake Gonzales,
Angelene M. Cantwell,
Rolando Garza,
Gabriel Catano,
Robin E. Tragus,
Thomas F. Patterson,
Sebastiaan Bol,
Evelien M. Bunnik

Published: December 22, 2021
https://doi.org/10.1371/journal.pone.0261656

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