Grxcr1 regulates hair bundle morphogenesis and is required for normal mechanoelectrical transduction in mouse cochlear hair cells

Beatriz Lorente-Cánovas; Stephanie Eckrich; Morag A. Lewis; Stuart L. Johnson; Walter Marcotti; Karen P. Steel

doi:10.1371/journal.pone.0261530

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Peer-reviewed

Research Article

Grxcr1 regulates hair bundle morphogenesis and is required for normal mechanoelectrical transduction in mouse cochlear hair cells

Beatriz Lorente-Cánovas,

Roles Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliations Wolfson Centre for Age-Related Diseases, King’s College London, London, United Kingdom, Wellcome Sanger Institute, Hinxton, United Kingdom
⨯
Stephanie Eckrich,

Roles Investigation, Methodology, Writing – review & editing

Current address: Department of Biophysics, Center for Integrative Physiology and Molecular Medicine (CIPMM), School of Medicine, Saarland University, Homburg, Germany

Affiliation School of Biosciences, University of Sheffield, Sheffield, United Kingdom

https://orcid.org/0000-0001-6633-9478

⨯
Morag A. Lewis,

Roles Formal analysis, Writing – original draft, Writing – review & editing

Affiliations Wolfson Centre for Age-Related Diseases, King’s College London, London, United Kingdom, Wellcome Sanger Institute, Hinxton, United Kingdom

https://orcid.org/0000-0002-1846-8600

⨯
Stuart L. Johnson,

Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliations School of Biosciences, University of Sheffield, Sheffield, United Kingdom, Neuroscience Institute, University of Sheffield, Sheffield, United Kingdom
⨯
Walter Marcotti ,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

¶‡ WM and KPS are joint senior authors on this work.

Affiliations School of Biosciences, University of Sheffield, Sheffield, United Kingdom, Neuroscience Institute, University of Sheffield, Sheffield, United Kingdom
⨯
Karen P. Steel

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: karen.steel@kcl.ac.uk

¶‡ WM and KPS are joint senior authors on this work.

Affiliations Wolfson Centre for Age-Related Diseases, King’s College London, London, United Kingdom, Wellcome Sanger Institute, Hinxton, United Kingdom

https://orcid.org/0000-0002-8019-5359

⨯

Grxcr1 regulates hair bundle morphogenesis and is required for normal mechanoelectrical transduction in mouse cochlear hair cells

Beatriz Lorente-Cánovas,
Stephanie Eckrich,
Morag A. Lewis,
Stuart L. Johnson,
Walter Marcotti,
Karen P. Steel

Published: March 2, 2022
https://doi.org/10.1371/journal.pone.0261530

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