Preloaded D-methionine protects from steady state and impulse noise-induced hearing loss and induces long-term cochlear and endogenous antioxidant effects

Kathleen Campbell; Nicole Cosenza; Robert Meech; Michael Buhnerkempe; Jun Qin; Leonard Rybak; Daniel Fox

doi:10.1371/journal.pone.0261049

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Open Access

Peer-reviewed

Research Article

Preloaded D-methionine protects from steady state and impulse noise-induced hearing loss and induces long-term cochlear and endogenous antioxidant effects

Kathleen Campbell ,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: kcampbell@siumed.edu

Affiliation Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America

https://orcid.org/0000-0001-7417-0545

⨯
Nicole Cosenza,

Roles Formal analysis, Project administration, Supervision

Affiliation Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America
⨯
Robert Meech,

Roles Data curation, Formal analysis, Methodology, Project administration, Supervision, Validation

Affiliation Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America
⨯
Michael Buhnerkempe,

Roles Data curation, Formal analysis, Writing – review & editing

Affiliation Department of Internal Medicine, Statistics, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America
⨯
Jun Qin,

Roles Methodology, Software, Validation

Affiliation Department of Engineering, Southern Illinois University, Carbondale, Illinois, United States of America
⨯
Leonard Rybak,

Roles Conceptualization, Funding acquisition, Writing – review & editing

Affiliation Department of Otolaryngology Head and Neck Surgery, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America
⨯
Daniel Fox

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Clinical Research, Springfield Clinic, Springfield, Illinois, United States of America
⨯

Preloaded D-methionine protects from steady state and impulse noise-induced hearing loss and induces long-term cochlear and endogenous antioxidant effects

Kathleen Campbell,
Nicole Cosenza,
Robert Meech,
Michael Buhnerkempe,
Jun Qin,
Leonard Rybak,
Daniel Fox

Published: December 8, 2021
https://doi.org/10.1371/journal.pone.0261049

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