Assessing BRCA1 activity in DNA damage repair using human induced pluripotent stem cells as an approach to assist classification of BRCA1 variants of uncertain significance

• Meryem Ozgencil,

  Roles Funding acquisition, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  Current address: Centre for Cancer Cell & Molecular Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Centre, Charterhouse Square, London, United Kingdom

  Affiliation Department of Medical & Molecular Genetics, King’s College London, Faculty of Life Sciences & Medicine, London, United Kingdom

  ⨯
• Julian Barwell,

  Roles Resources, Writing – review & editing

  Affiliation Department of Genetics and Genome Biology at the University of Leicester, Leicester, United Kingdom

  ⨯
• Marc Tischkowitz,

  Roles Resources, Writing – review & editing

  Affiliation Department of Medical Genetics, National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, United Kingdom

  ⨯
• Louise Izatt,

  Roles Resources, Writing – review & editing

  Affiliation Clinical Genetics, Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom

  ⨯
• Ian Kesterton,

  Roles Investigation, Writing – review & editing

  Affiliation Cytogenetics Laboratory, Viapath Analytics, Guy’s and St. Thomas’ NHS Foundation Trust, Guy’s Hospital, London, United Kingdom

  ⨯
• Michael Simpson,

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Department of Medical & Molecular Genetics, King’s College London, Faculty of Life Sciences & Medicine, London, United Kingdom

  ⨯
• Paul Sharpe,

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Department of Craniofacial Development & Stem Cell Biology, King’s College London, London, United Kingdom

  ⨯
• Paulo de Sepulveda,

  Roles Resources, Writing – review & editing

  Affiliation Signaling Hematopoiesis and Mechanism of Oncogenesis Lab, INSERM, CNRS, Institut Paoli-Calmettes, CRCM, Aix Marseille University, Marseille, France

  https://orcid.org/0000-0001-8295-5414

  ⨯
• Edwige Voisset ,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: edwige.voisset@inserm.fr (EV); ellen.solomon@kcl.ac.uk (ES)

  ¶‡ EV and ES are Co-last authors on this work.

  Affiliation Department of Medical & Molecular Genetics, King’s College London, Faculty of Life Sciences & Medicine, London, United Kingdom

  https://orcid.org/0000-0002-0943-4847

  ⨯
• Ellen Solomon

  Roles Conceptualization, Funding acquisition, Writing – review & editing

  * E-mail: edwige.voisset@inserm.fr (EV); ellen.solomon@kcl.ac.uk (ES)

  ¶‡ EV and ES are Co-last authors on this work.

  Affiliation Department of Medical & Molecular Genetics, King’s College London, Faculty of Life Sciences & Medicine, London, United Kingdom

  ⨯