Comparison of TCF4 repeat expansion length in corneal endothelium and leukocytes of patients with Fuchs endothelial corneal dystrophy

Eric D. Wieben; Ross A. Aleff; Tommy A. Rinkoski; Keith H. Baratz; Shubham Basu; Sanjay V. Patel; Leo J. Maguire; Michael P. Fautsch

doi:10.1371/journal.pone.0260837

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Open Access

Peer-reviewed

Research Article

Comparison of TCF4 repeat expansion length in corneal endothelium and leukocytes of patients with Fuchs endothelial corneal dystrophy

Eric D. Wieben,

Roles Conceptualization, Data curation, Formal analysis, Project administration, Validation, Writing – original draft, Writing – review & editing

Affiliation Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United states of America
⨯
Ross A. Aleff,

Roles Data curation, Investigation, Writing – review & editing

Affiliation Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United states of America
⨯
Tommy A. Rinkoski,

Roles Data curation, Formal analysis, Writing – review & editing

Affiliation Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, United states of America
⨯
Keith H. Baratz,

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

Affiliation Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, United states of America
⨯
Shubham Basu,

Roles Data curation, Formal analysis, Writing – review & editing

Affiliation Division of Biostatistics and Bioinformatics and Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Sanjay V. Patel,

Roles Data curation, Methodology, Writing – review & editing

Affiliation Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, United states of America

https://orcid.org/0000-0001-6694-1530

⨯
Leo J. Maguire,

Roles Data curation, Methodology, Writing – review & editing

Affiliation Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, United states of America
⨯
Michael P. Fautsch

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing

* E-mail: fautsch@mayo.edu

Affiliation Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, United states of America

https://orcid.org/0000-0002-9115-2485

⨯

Comparison of TCF4 repeat expansion length in corneal endothelium and leukocytes of patients with Fuchs endothelial corneal dystrophy

Eric D. Wieben,
Ross A. Aleff,
Tommy A. Rinkoski,
Keith H. Baratz,
Shubham Basu,
Sanjay V. Patel,
Leo J. Maguire,
Michael P. Fautsch

Published: December 2, 2021
https://doi.org/10.1371/journal.pone.0260837

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Corneal disorders
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Cornea
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White blood cells
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Endothelium
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Southern blot
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Tandem repeats
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