PNPLA3 downregulation exacerbates the fibrotic response in human hepatic stellate cells

Brian Rady; Takahiro Nishio; Debanjan Dhar; Xiao Liu; Mark Erion; Tatiana Kisseleva; David A. Brenner; Alessandro Pocai

doi:10.1371/journal.pone.0260721

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Open Access

Peer-reviewed

Research Article

PNPLA3 downregulation exacerbates the fibrotic response in human hepatic stellate cells

Brian Rady ,

Contributed equally to this work with: Brian Rady, Takahiro Nishio

Roles Conceptualization, Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: Brianrady@gmail.com

Affiliation Cardiovascular & Metabolism, Janssen Pharmaceuticals, Spring House, PA, United States of America

https://orcid.org/0000-0001-5217-9354

⨯
Takahiro Nishio ,

Contributed equally to this work with: Brian Rady, Takahiro Nishio

Roles Conceptualization, Writing – original draft

Affiliation Department of Medicine, University of California San Diego, La Jolla, CA, United States of America

https://orcid.org/0000-0002-9676-7235

⨯
Debanjan Dhar,

Roles Conceptualization, Formal analysis, Investigation, Writing – original draft

Affiliation Department of Medicine, University of California San Diego, La Jolla, CA, United States of America
⨯
Xiao Liu,

Roles Conceptualization, Formal analysis, Investigation, Writing – original draft

Affiliation Department of Medicine, University of California San Diego, La Jolla, CA, United States of America
⨯
Mark Erion,

Roles Conceptualization

Affiliation Cardiovascular & Metabolism, Janssen Pharmaceuticals, Spring House, PA, United States of America
⨯
Tatiana Kisseleva,

Roles Conceptualization, Writing – original draft

Affiliation Department of Medicine, University of California San Diego, La Jolla, CA, United States of America
⨯
David A. Brenner,

Roles Conceptualization, Formal analysis, Writing – original draft

Affiliation Department of Medicine, University of California San Diego, La Jolla, CA, United States of America
⨯
Alessandro Pocai

Roles Conceptualization, Formal analysis, Writing – original draft

Affiliation Cardiovascular & Metabolism, Janssen Pharmaceuticals, Spring House, PA, United States of America

https://orcid.org/0000-0003-1450-9521

⨯

PNPLA3 downregulation exacerbates the fibrotic response in human hepatic stellate cells

Brian Rady,
Takahiro Nishio,
Debanjan Dhar,
Xiao Liu,
Mark Erion,
Tatiana Kisseleva,
David A. Brenner,
Alessandro Pocai

Published: December 8, 2021
https://doi.org/10.1371/journal.pone.0260721

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Small interfering RNA
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Fibrosis
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Homozygosity
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Hepatocytes
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Fatty liver
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Single nucleotide polymorphisms
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Gene expression
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