Central nervous system infection in the intensive care unit: Development and validation of a multi-parameter diagnostic prediction tool to identify suspected patients

• Hugo Boechat Andrade ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: hugo.boechat@ini.fiocruz.br

  Affiliations Intensive Care Unit, Evandro Chagas National Institute of Infectious Diseases (INI), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, RJ, Brazil, Sexually Transmitted Diseases Sector, Biomedical Institute, Universidade Federal Fluminense (UFF), Niterói, RJ, Brazil

  https://orcid.org/0000-0001-6781-6125

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• Ivan Rocha Ferreira da Silva,

  Roles Formal analysis, Investigation, Validation, Writing – review & editing

  Affiliation Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, United States of America

  https://orcid.org/0000-0001-8572-9631

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• Justin Lee Sim,

  Roles Investigation, Validation

  Affiliation Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, United States of America

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• José Henrique Mello-Neto,

  Roles Formal analysis, Investigation, Resources, Validation

  Affiliation Intensive Care Unit, Evandro Chagas National Institute of Infectious Diseases (INI), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, RJ, Brazil

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• Pedro Henrique Nascimento Theodoro,

  Roles Investigation, Validation

  Affiliation Intensive Care Unit, Evandro Chagas National Institute of Infectious Diseases (INI), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, RJ, Brazil

  https://orcid.org/0000-0003-3197-2999

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• Mayara Secco Torres da Silva,

  Roles Formal analysis, Investigation

  Affiliation Intensive Care Unit, Evandro Chagas National Institute of Infectious Diseases (INI), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, RJ, Brazil

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• Margareth Catoia Varela,

  Roles Data curation, Formal analysis, Investigation, Software

  Affiliation Immunization and Health Surveillance Research Laboratory, Evandro Chagas National Institute of Infectious Diseases (INI), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, RJ, Brazil

  https://orcid.org/0000-0002-8161-1158

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• Grazielle Viana Ramos,

  Roles Data curation, Investigation, Resources

  Affiliation Department of Critical Care, D’Or Institute for Research and Education, Rio de Janeiro, RJ, Brazil

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• Aline Ramos da Silva,

  Roles Data curation, Formal analysis, Validation

  Affiliation Department of Critical Care, D’Or Institute for Research and Education, Rio de Janeiro, RJ, Brazil

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• Fernando Augusto Bozza,

  Roles Conceptualization, Methodology, Supervision, Writing – review & editing

  Affiliations Intensive Care Unit, Evandro Chagas National Institute of Infectious Diseases (INI), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, RJ, Brazil, Department of Critical Care, D’Or Institute for Research and Education, Rio de Janeiro, RJ, Brazil

  https://orcid.org/0000-0003-4878-0256

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• Jesus Soares,

  Roles Supervision, Writing – review & editing

  Affiliation Division of High-Consequence Pathology and Pathogens, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States of America

  https://orcid.org/0000-0002-8640-8618

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• Ermias D. Belay,

  Roles Funding acquisition, Resources, Supervision, Writing – review & editing

  Affiliation Division of High-Consequence Pathology and Pathogens, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States of America

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• James J. Sejvar,

  Roles Conceptualization, Writing – review & editing

  Affiliation Division of High-Consequence Pathology and Pathogens, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States of America

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• José Cerbino-Neto,

  Roles Funding acquisition, Methodology, Project administration, Resources, Visualization, Writing – review & editing

  Affiliation Immunization and Health Surveillance Research Laboratory, Evandro Chagas National Institute of Infectious Diseases (INI), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, RJ, Brazil

  https://orcid.org/0000-0001-9254-917X

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• André Miguel Japiassú

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Project administration, Supervision, Visualization, Writing – review & editing

  Affiliation Intensive Care Unit, Evandro Chagas National Institute of Infectious Diseases (INI), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, RJ, Brazil

  https://orcid.org/0000-0002-9444-9890

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