Plasma obtained following murine hindlimb ischemic conditioning protects against oxidative stress in zebrafish models through activation of nrf2a and downregulation of duox

• Rui Guan,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Zebrafish Centre for Advanced Drug Discovery, The Keenan Research Centre for Biomedical Science Toronto, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Ontario, Canada, Department of Medicine & Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada

  https://orcid.org/0000-0002-4450-2817

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• Xiao-yan Wen,

  Roles Resources, Supervision, Writing – review & editing

  Affiliations Zebrafish Centre for Advanced Drug Discovery, The Keenan Research Centre for Biomedical Science Toronto, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Ontario, Canada, Department of Medicine & Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada

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• Chung Ho Leung,

  Roles Investigation

  Affiliations Department of Medicine & Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada, Departments of Surgery, St. Michael’s Hospital and University of Toronto, Toronto, Ontario, Canada

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• Caterina Di Ciano-Oliveira,

  Roles Methodology

  Affiliations Zebrafish Centre for Advanced Drug Discovery, The Keenan Research Centre for Biomedical Science Toronto, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Ontario, Canada, Departments of Surgery, St. Michael’s Hospital and University of Toronto, Toronto, Ontario, Canada

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• Stephen Lam,

  Roles Methodology

  Affiliation Department of Medicine & Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada

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• Si Yuan Dai,

  Roles Investigation

  Affiliation Department of Medicine & Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada

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• Farhad Karbassi ,

  Roles Writing – review & editing

  * E-mail: Ori.Rotstein@unityhealth.to (OR); x.wen@utoronto.ca (XW)

  Affiliations Zebrafish Centre for Advanced Drug Discovery, The Keenan Research Centre for Biomedical Science Toronto, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Ontario, Canada, Department of Medicine & Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada, Departments of Surgery, St. Michael’s Hospital and University of Toronto, Toronto, Ontario, Canada

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• Antonio Mauro ,

  Roles Writing – review & editing

  * E-mail: Ori.Rotstein@unityhealth.to (OR); x.wen@utoronto.ca (XW)

  Affiliations Zebrafish Centre for Advanced Drug Discovery, The Keenan Research Centre for Biomedical Science Toronto, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Ontario, Canada, Department of Medicine & Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada, Departments of Surgery, St. Michael’s Hospital and University of Toronto, Toronto, Ontario, Canada

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• Youdong Wang ,

  Roles Methodology

  * E-mail: Ori.Rotstein@unityhealth.to (OR); x.wen@utoronto.ca (XW)

  Affiliations Zebrafish Centre for Advanced Drug Discovery, The Keenan Research Centre for Biomedical Science Toronto, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Ontario, Canada, Department of Medicine & Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada, Departments of Surgery, St. Michael’s Hospital and University of Toronto, Toronto, Ontario, Canada

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• Ori Rotstein

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  * E-mail: Ori.Rotstein@unityhealth.to (OR); x.wen@utoronto.ca (XW)

  Affiliations Zebrafish Centre for Advanced Drug Discovery, The Keenan Research Centre for Biomedical Science Toronto, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Ontario, Canada, Department of Medicine & Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada, Departments of Surgery, St. Michael’s Hospital and University of Toronto, Toronto, Ontario, Canada

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