Mutational landscape of SARS-CoV-2 genome in Turkey and impact of mutations on spike protein structure

Ozden Hatirnaz Ng; Sezer Akyoney; Ilayda Sahin; Huseyin Okan Soykam; Gunseli Bayram Akcapinar; Ozkan Ozdemir; Derya Dilek Kancagi; Gozde Sir Karakus; Bulut Yurtsever; Ayse Sesin Kocagoz; Ercument Ovali; Ugur Ozbek

doi:10.1371/journal.pone.0260438

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Open Access

Peer-reviewed

Research Article

Mutational landscape of SARS-CoV-2 genome in Turkey and impact of mutations on spike protein structure

Ozden Hatirnaz Ng,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Supervision, Writing – original draft

Affiliations Department of Medical Biology, Acibadem Mehmet Ali Aydinlar University School of Medicine, Istanbul, Turkey, Acibadem Mehmet Ali Aydinlar University Rare Diseases and Orphan Drugs Application and Research Center (ACURARE), Istanbul, Turkey
⨯
Sezer Akyoney ,

Contributed equally to this work with: Sezer Akyoney, Ilayda Sahin

Roles Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft

Affiliations Department of Medical Biology, Acibadem Mehmet Ali Aydinlar University School of Medicine, Istanbul, Turkey, Department of Biostatistics and Bioinformatics, Institute of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey
⨯
Ilayda Sahin ,

Contributed equally to this work with: Sezer Akyoney, Ilayda Sahin

Roles Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft

Affiliations Department of Medical Biotechnology, Institute of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey, Department of Medical Genetics, Acibadem Mehmet Ali Aydinlar University School of Medicine, Istanbul, Turkey
⨯
Huseyin Okan Soykam,

Roles Formal analysis, Methodology, Software, Visualization, Writing – original draft

Affiliation Department of Biostatistics and Bioinformatics, Institute of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey
⨯
Gunseli Bayram Akcapinar,

Roles Formal analysis, Methodology, Software, Visualization, Writing – original draft

Affiliation Department of Medical Biotechnology, Institute of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey
⨯
Ozkan Ozdemir,

Roles Data curation, Formal analysis, Methodology, Software, Visualization, Writing – review & editing

Affiliations Acibadem Mehmet Ali Aydinlar University Rare Diseases and Orphan Drugs Application and Research Center (ACURARE), Istanbul, Turkey, Department of Genome Studies, Institute of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey
⨯
Derya Dilek Kancagi,

Roles Investigation, Resources

Affiliation Acibadem Labcell Cellular Therapy Laboratory, Istanbul, Turkey
⨯
Gozde Sir Karakus,

Roles Investigation, Resources

Affiliation Acibadem Labcell Cellular Therapy Laboratory, Istanbul, Turkey
⨯
Bulut Yurtsever,

Roles Investigation, Resources

Affiliation Acibadem Labcell Cellular Therapy Laboratory, Istanbul, Turkey
⨯
Ayse Sesin Kocagoz,

Roles Resources, Writing – review & editing

Affiliation Department of Infectious Diseases and Clinical Microbiology, Acibadem Mehmet Ali Aydinlar University School of Medicine, Istanbul, Turkey
⨯
Ercument Ovali,

Roles Funding acquisition, Writing – review & editing

Affiliation Acibadem Labcell Cellular Therapy Laboratory, Istanbul, Turkey
⨯
Ugur Ozbek

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

* E-mail: ugur.ozbek@acibadem.edu.tr

Affiliations Acibadem Mehmet Ali Aydinlar University Rare Diseases and Orphan Drugs Application and Research Center (ACURARE), Istanbul, Turkey, Department of Medical Genetics, Acibadem Mehmet Ali Aydinlar University School of Medicine, Istanbul, Turkey

https://orcid.org/0000-0001-5319-0547

⨯

Mutational landscape of SARS-CoV-2 genome in Turkey and impact of mutations on spike protein structure

Ozden Hatirnaz Ng,
Sezer Akyoney,
Ilayda Sahin,
Huseyin Okan Soykam,
Gunseli Bayram Akcapinar,
Ozkan Ozdemir,
Derya Dilek Kancagi,
Gozde Sir Karakus,
Bulut Yurtsever,
Ayse Sesin Kocagoz

Published: December 6, 2021
https://doi.org/10.1371/journal.pone.0260438

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