Towards risk stratification and prediction of disease severity and mortality in COVID-19: Next generation metabolomics for the measurement of host response to COVID-19 infection

• Paulo D’Amora ,

  Contributed equally to this work with: Paulo D’Amora, Ismael Dale C. G. Silva, Maria Auxiliadora Budib

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: d.amora@unifesp.br

  Affiliations Department of Gynecology, Molecular Gynecology and Metabolomics Lab, College of Medicine of the Federal University of São Paulo (EPM-UNIFESP), São Paulo, São Paulo, Brazil, Nagourney Institute, Long Beach, California, United States of America, Metabolomycs, Inc., Long Beach, California, United States of America

  https://orcid.org/0000-0003-2341-5340

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• Ismael Dale C. G. Silva ,

  Contributed equally to this work with: Paulo D’Amora, Ismael Dale C. G. Silva, Maria Auxiliadora Budib

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing – review & editing

  ¶‡ RA, RMSS, FCS, RMA, SSJ, HBDP, ACA, and ECA also contributed equally to this work. IDCGS, RSD and RAN are joint senior authors on this work.

  Affiliations Department of Gynecology, Molecular Gynecology and Metabolomics Lab, College of Medicine of the Federal University of São Paulo (EPM-UNIFESP), São Paulo, São Paulo, Brazil, Nagourney Cancer Institute, Long Beach, California, United States of America

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• Maria Auxiliadora Budib ,

  Contributed equally to this work with: Paulo D’Amora, Ismael Dale C. G. Silva, Maria Auxiliadora Budib

  Roles Data curation, Investigation, Resources

  Affiliation Department of Emergency and Intensive Care Unit, CASSEMS Hospital, Campo Grande, Mato Grosso do Sul, Brazil

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• Ricardo Ayache ,

  Roles Data curation, Investigation, Resources

  ¶‡ RA, RMSS, FCS, RMA, SSJ, HBDP, ACA, and ECA also contributed equally to this work. IDCGS, RSD and RAN are joint senior authors on this work.

  Affiliation Department of Emergency and Intensive Care Unit, CASSEMS Hospital, Campo Grande, Mato Grosso do Sul, Brazil

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• Rafaela Moraes Siufi Silva ,

  Roles Data curation, Investigation, Resources

  ¶‡ RA, RMSS, FCS, RMA, SSJ, HBDP, ACA, and ECA also contributed equally to this work. IDCGS, RSD and RAN are joint senior authors on this work.

  Affiliation Department of Emergency and Intensive Care Unit, CASSEMS Hospital, Campo Grande, Mato Grosso do Sul, Brazil

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• Fabricio Colacino Silva ,

  Roles Data curation, Investigation, Resources

  ¶‡ RA, RMSS, FCS, RMA, SSJ, HBDP, ACA, and ECA also contributed equally to this work. IDCGS, RSD and RAN are joint senior authors on this work.

  Affiliation Department of Emergency and Intensive Care Unit, CASSEMS Hospital, Campo Grande, Mato Grosso do Sul, Brazil

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• Robson Mateus Appel ,

  Roles Data curation, Investigation, Resources

  ¶‡ RA, RMSS, FCS, RMA, SSJ, HBDP, ACA, and ECA also contributed equally to this work. IDCGS, RSD and RAN are joint senior authors on this work.

  Affiliation Department of Emergency and Intensive Care Unit, CASSEMS Hospital, Campo Grande, Mato Grosso do Sul, Brazil

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• Saturnino Sarat Júnior ,

  Roles Data curation, Investigation, Resources

  ¶‡ RA, RMSS, FCS, RMA, SSJ, HBDP, ACA, and ECA also contributed equally to this work. IDCGS, RSD and RAN are joint senior authors on this work.

  Affiliation Department of Emergency and Intensive Care Unit, CASSEMS Hospital, Campo Grande, Mato Grosso do Sul, Brazil

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• Henrique Budib Dorsa Pontes ,

  Roles Data curation, Investigation, Resources

  ¶‡ RA, RMSS, FCS, RMA, SSJ, HBDP, ACA, and ECA also contributed equally to this work. IDCGS, RSD and RAN are joint senior authors on this work.

  Affiliation Department of Emergency and Intensive Care Unit, CASSEMS Hospital, Campo Grande, Mato Grosso do Sul, Brazil

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• Ana Carolina Alvarenga ,

  Roles Data curation, Investigation, Resources

  ¶‡ RA, RMSS, FCS, RMA, SSJ, HBDP, ACA, and ECA also contributed equally to this work. IDCGS, RSD and RAN are joint senior authors on this work.

  Affiliation Department of Emergency and Intensive Care Unit, CASSEMS Hospital, Campo Grande, Mato Grosso do Sul, Brazil

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• Emilli Carvalho Arima ,

  Roles Data curation, Investigation, Resources

  ¶‡ RA, RMSS, FCS, RMA, SSJ, HBDP, ACA, and ECA also contributed equally to this work. IDCGS, RSD and RAN are joint senior authors on this work.

  Affiliation Department of Emergency and Intensive Care Unit, CASSEMS Hospital, Campo Grande, Mato Grosso do Sul, Brazil

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• Wellington Galhano Martins,

  Roles Data curation, Investigation, Resources

  Affiliation Department of Emergency and Intensive Care Unit, CASSEMS Hospital, Campo Grande, Mato Grosso do Sul, Brazil

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• Nakal Laurenço F. Silva,

  Roles Data curation, Investigation, Resources

  Affiliation Department of Emergency and Intensive Care Unit, CASSEMS Hospital, Campo Grande, Mato Grosso do Sul, Brazil

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• Ricardo Sobhie Diaz ,

  Roles Data curation, Investigation, Resources, Supervision

  ¶‡ RA, RMSS, FCS, RMA, SSJ, HBDP, ACA, and ECA also contributed equally to this work. IDCGS, RSD and RAN are joint senior authors on this work.

  Affiliation Department of Medicine, Infectious Disease Division, Retrovirology Laboratory, College of Medicine of the Federal University of São Paulo (EPM-UNIFESP), São Paulo, São Paulo, Brazil

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• Marcia B. Salzgeber,

  Roles Data curation, Investigation, Resources

  Affiliation Department of Gynecology, Molecular Gynecology and Metabolomics Lab, College of Medicine of the Federal University of São Paulo (EPM-UNIFESP), São Paulo, São Paulo, Brazil

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• Anton M. Palma,

  Roles Data curation, Formal analysis, Methodology, Validation

  Affiliation Institute for Clinical and Translational Science (ICTS), University of California Irvine (UCI), Irvine, California, United States of America

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• Steven S. Evans,

  Roles Data curation, Investigation, Resources, Supervision

  Affiliations Nagourney Institute, Long Beach, California, United States of America, Metabolomycs, Inc., Long Beach, California, United States of America, Nagourney Cancer Institute, Long Beach, California, United States of America

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•  [ ... ],
• Robert A. Nagourney

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – review & editing

  ¶‡ RA, RMSS, FCS, RMA, SSJ, HBDP, ACA, and ECA also contributed equally to this work. IDCGS, RSD and RAN are joint senior authors on this work.

  Affiliations Nagourney Institute, Long Beach, California, United States of America, Metabolomycs, Inc., Long Beach, California, United States of America, Nagourney Cancer Institute, Long Beach, California, United States of America, Todd Cancer Institute, Memorial Medical Center of Long Beach, Long Beach, California, United States of America, Department of Obstetrics and Gynecology, University of California Irvine (UCI), Orange, California, United States of America

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