Gut microbiome affects the metabolism of metronidazole in mice through regulation of hepatic cytochromes P450 expression

Nina Zemanová; Kateřina Lněničková; Markéta Vavrečková; Eva Anzenbacherová; Pavel Anzenbacher; Iveta Zapletalová; Petra Hermanová; Tomáš Hudcovic; Hana Kozáková; Lenka Jourová

doi:10.1371/journal.pone.0259643

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Open Access

Peer-reviewed

Research Article

Gut microbiome affects the metabolism of metronidazole in mice through regulation of hepatic cytochromes P450 expression

Nina Zemanová,

Roles Formal analysis, Validation, Writing – original draft

Affiliation Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic

https://orcid.org/0000-0001-9356-1381

⨯
Kateřina Lněničková,

Roles Formal analysis, Validation, Writing – review & editing

Affiliation Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic

https://orcid.org/0000-0003-1510-7751

⨯
Markéta Vavrečková,

Roles Formal analysis

Affiliation Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic
⨯
Eva Anzenbacherová,

Roles Conceptualization, Project administration, Supervision, Writing – review & editing

Affiliation Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic
⨯
Pavel Anzenbacher,

Roles Writing – review & editing

Affiliation Department of Pharmacology, Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic
⨯
Iveta Zapletalová,

Roles Formal analysis

Affiliation Department of Pharmacology, Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic
⨯
Petra Hermanová,

Roles Formal analysis, Methodology

Affiliation Laboratory of Gnotobiology, Institute of Microbiology of the Czech Academy of Sciences, Nový Hrádek, Czech Republic
⨯
Tomáš Hudcovic,

Roles Data curation, Formal analysis, Methodology

Affiliation Laboratory of Gnotobiology, Institute of Microbiology of the Czech Academy of Sciences, Nový Hrádek, Czech Republic
⨯
Hana Kozáková,

Roles Project administration, Writing – review & editing

Affiliation Laboratory of Gnotobiology, Institute of Microbiology of the Czech Academy of Sciences, Nový Hrádek, Czech Republic
⨯
Lenka Jourová

Roles Formal analysis, Writing – review & editing

* E-mail: LenkaJourova@seznam.cz

Affiliation Department of Medical Chemistry and Biochemistry, Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic

https://orcid.org/0000-0003-3195-6710

⨯

Gut microbiome affects the metabolism of metronidazole in mice through regulation of hepatic cytochromes P450 expression

Nina Zemanová,
Kateřina Lněničková,
Markéta Vavrečková,
Eva Anzenbacherová,
Pavel Anzenbacher,
Iveta Zapletalová,
Petra Hermanová,
Tomáš Hudcovic,
Hana Kozáková,
Lenka Jourová

Published: November 9, 2021
https://doi.org/10.1371/journal.pone.0259643

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Enzyme metabolism
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Microbiome
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Gut bacteria
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Protein expression
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