Blockade of beta adrenergic receptors protects the blood brain barrier and reduces systemic pathology caused by HIV-1 Nef protein

• Jocelyn Rivera-Ortiz,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  Affiliation HIV-1 Immunopathogenesis Laboratory, The Wistar Institute, Philadelphia, PA, United States of America

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• Jessalyn Pla-Tenorio,

  Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Basic Sciences, Ponce Health Sciences University, Ponce Research Institute, Ponce, Puerto Rico

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• Myrella L. Cruz,

  Roles Data curation, Formal analysis, Investigation, Methodology, Supervision, Writing – review & editing

  Affiliation Department of Basic Sciences, Ponce Health Sciences University, Ponce Research Institute, Ponce, Puerto Rico

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• Krystal Colon,

  Roles Writing – original draft, Writing – review & editing

  Affiliation HIV-1 Immunopathogenesis Laboratory, The Wistar Institute, Philadelphia, PA, United States of America

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• Jaileene Perez-Morales,

  Roles Formal analysis, Methodology

  Affiliation Department of Basic Sciences, Ponce Health Sciences University, Ponce Research Institute, Ponce, Puerto Rico

  https://orcid.org/0000-0003-3569-2396

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• Julio A. Rodriguez Jr.,

  Roles Formal analysis, Writing – original draft, Writing – review & editing

  Affiliation Cooper University Hospital Department of Orthopaedic Surgery, Camden, NJ, United States of America

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• Jorge Martinez-Sicari,

  Roles Data curation, Formal analysis, Investigation, Writing – original draft

  Affiliation Department of Basic Sciences, Ponce Health Sciences University, Ponce Research Institute, Ponce, Puerto Rico

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• Richard J. Noel Jr.

  Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: rnoel@psm.edu

  Affiliation Department of Basic Sciences, Ponce Health Sciences University, Ponce Research Institute, Ponce, Puerto Rico

  https://orcid.org/0000-0002-0467-3777

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