Assessing reproducibility and utility of clustering of patients with type 2 diabetes and established CV disease (SAVOR -TIMI 53 trial)

Yasunori Aoki; Bengt Hamrén; Lindsay E. Clegg; Christina Stahre; Deepak L. Bhatt; Itamar Raz; Benjamin M. Scirica; Jan Oscarsson; Björn Carlsson

doi:10.1371/journal.pone.0259372

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Open Access

Peer-reviewed

Research Article

Assessing reproducibility and utility of clustering of patients with type 2 diabetes and established CV disease (SAVOR -TIMI 53 trial)

Yasunori Aoki ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft

* E-mail: yaoki@uwaterloo.ca

Affiliation Clinical Pharmacology and Safety Sciences, AstraZeneca, Gothenburg, Sweden

https://orcid.org/0000-0002-5881-2023

⨯
Bengt Hamrén,

Roles Conceptualization, Funding acquisition, Methodology, Resources, Supervision, Writing – review & editing

Affiliation Clinical Pharmacology and Safety Sciences, AstraZeneca, Gothenburg, Sweden
⨯
Lindsay E. Clegg,

Roles Data curation, Investigation, Writing – review & editing

Affiliation Clinical Pharmacology and Safety Sciences, AstraZeneca, Gaithersburg, MD, United States of America
⨯
Christina Stahre,

Roles Investigation, Resources, Writing – review & editing

Affiliation Late-Stage Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
⨯
Deepak L. Bhatt,

Roles Data curation, Resources, Writing – review & editing

Affiliations Brigham and Women’s Hospital Heart & Vascular Center, Boston, MA, United States of America, Harvard Medical School, Boston, MA, United States of America
⨯
Itamar Raz,

Roles Data curation, Resources, Writing – review & editing

Affiliation Hadassah University Hospital, Jerusalem, Israel
⨯
Benjamin M. Scirica,

Roles Data curation, Resources, Writing – review & editing

Affiliations Brigham and Women’s Hospital Heart & Vascular Center, Boston, MA, United States of America, Harvard Medical School, Boston, MA, United States of America
⨯
Jan Oscarsson,

Roles Conceptualization, Investigation, Methodology, Supervision, Writing – review & editing

Affiliation Late-Stage Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
⨯
Björn Carlsson

Roles Conceptualization, Investigation, Methodology, Validation, Writing – review & editing

Affiliation Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
⨯

Assessing reproducibility and utility of clustering of patients with type 2 diabetes and established CV disease (SAVOR -TIMI 53 trial)

Yasunori Aoki,
Bengt Hamrén,
Lindsay E. Clegg,
Christina Stahre,
Deepak L. Bhatt,
Itamar Raz,
Benjamin M. Scirica,
Jan Oscarsson,
Björn Carlsson

Published: November 19, 2021
https://doi.org/10.1371/journal.pone.0259372

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Diabetes mellitus
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HbA1c
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Medical risk factors
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k means clustering
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Type 2 diabetes
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Type 2 diabetes risk
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