In silico repurposing of a Novobiocin derivative for activity against latency associated Mycobacterium tuberculosis drug target nicotinate-nucleotide adenylyl transferase (Rv2421c)

• Ruben Cloete,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation South African Medical Research Council Bioinformatics Unit, South African National Bioinformatics Institute, University of the Western Cape, Bellville, South Africa

  https://orcid.org/0000-0003-1966-0212

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• Mohd Shahbaaz,

  Roles Formal analysis, Methodology, Writing – original draft, Writing – review & editing

  Affiliation South African Medical Research Council Bioinformatics Unit, South African National Bioinformatics Institute, University of the Western Cape, Bellville, South Africa

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• Melanie Grobbelaar,

  Roles Formal analysis, Methodology, Validation, Writing – review & editing

  Affiliation Faculty of Medicine and Health Sciences, Division of Molecular Biology and Human Genetics, DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Stellenbosch, Cape Town, South Africa

  https://orcid.org/0000-0001-8138-5376

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• Samantha L. Sampson,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Faculty of Medicine and Health Sciences, Division of Molecular Biology and Human Genetics, DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Stellenbosch University, Stellenbosch, Cape Town, South Africa

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• Alan Christoffels

  Roles Funding acquisition, Resources, Supervision, Writing – review & editing

  * E-mail: alan@sanbi.ac.za

  Affiliation South African Medical Research Council Bioinformatics Unit, South African National Bioinformatics Institute, University of the Western Cape, Bellville, South Africa

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