Reactive oxygen species prevent lysosome coalescence during PIKfyve inhibition

• Golam T. Saffi,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Molecular Science Graduate Program, Ryerson University, Toronto, Ontario, Canada, Department of Chemistry and Biology, Ryerson University, Toronto, Ontario, Canada, Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario, Canada

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• Evan Tang,

  Roles Formal analysis, Investigation, Methodology, Visualization

  Affiliation Department of Chemistry and Biology, Ryerson University, Toronto, Ontario, Canada

  https://orcid.org/0000-0002-1241-2446

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• Sami Mamand,

  Roles Formal analysis, Investigation, Methodology, Visualization

  Affiliations Molecular Science Graduate Program, Ryerson University, Toronto, Ontario, Canada, Polytechnic Research Center, Erbil Polytechnic University, Kurdistan Regional Government, Erbil, Kurdistan

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• Subothan Inpanathan,

  Roles Formal analysis, Investigation, Methodology, Visualization

  Affiliations Molecular Science Graduate Program, Ryerson University, Toronto, Ontario, Canada, Department of Chemistry and Biology, Ryerson University, Toronto, Ontario, Canada

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• Aaron Fountain,

  Roles Formal analysis, Investigation, Methodology, Visualization

  Affiliations Molecular Science Graduate Program, Ryerson University, Toronto, Ontario, Canada, Department of Chemistry and Biology, Ryerson University, Toronto, Ontario, Canada

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• Leonardo Salmena,

  Roles Resources, Supervision, Writing – review & editing

  Affiliations Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario, Canada, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada

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• Roberto J. Botelho

  Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: rbotelho@ryerson.ca

  Affiliations Molecular Science Graduate Program, Ryerson University, Toronto, Ontario, Canada, Department of Chemistry and Biology, Ryerson University, Toronto, Ontario, Canada

  https://orcid.org/0000-0002-7820-0999

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