Intratumoral expression of IL-12 from lentiviral or RNA vectors acts synergistically with TLR4 agonist (GLA) to generate anti-tumor immunological memory

Jardin A. Leleux; Tina C. Albershardt; Rebecca Reeves; Reice James; Jordan Krull; Andrea J. Parsons; Jan ter Meulen; Peter Berglund

doi:10.1371/journal.pone.0259301

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Peer-reviewed

Research Article

Intratumoral expression of IL-12 from lentiviral or RNA vectors acts synergistically with TLR4 agonist (GLA) to generate anti-tumor immunological memory

Jardin A. Leleux ,

Contributed equally to this work with: Jardin A. Leleux, Tina C. Albershardt

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

* E-mail: jardin.leleux@gmail.com

Affiliation Immune Design Corp., Seattle, WA, A wholly owned subsidiary of Merck & Co., Inc., Kenilworth, NJ, United States of America

https://orcid.org/0000-0001-8668-0569

⨯
Tina C. Albershardt ,

Contributed equally to this work with: Jardin A. Leleux, Tina C. Albershardt

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

Affiliation Immune Design Corp., Seattle, WA, A wholly owned subsidiary of Merck & Co., Inc., Kenilworth, NJ, United States of America
⨯
Rebecca Reeves,

Roles Investigation

Affiliation Immune Design Corp., Seattle, WA, A wholly owned subsidiary of Merck & Co., Inc., Kenilworth, NJ, United States of America
⨯
Reice James,

Roles Investigation

Affiliation Immune Design Corp., Seattle, WA, A wholly owned subsidiary of Merck & Co., Inc., Kenilworth, NJ, United States of America
⨯
Jordan Krull,

Roles Investigation

Affiliation Immune Design Corp., Seattle, WA, A wholly owned subsidiary of Merck & Co., Inc., Kenilworth, NJ, United States of America
⨯
Andrea J. Parsons,

Roles Investigation

Affiliation Immune Design Corp., Seattle, WA, A wholly owned subsidiary of Merck & Co., Inc., Kenilworth, NJ, United States of America
⨯
Jan ter Meulen,

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

Affiliation Immune Design Corp., Seattle, WA, A wholly owned subsidiary of Merck & Co., Inc., Kenilworth, NJ, United States of America
⨯
Peter Berglund

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

Affiliation Immune Design Corp., Seattle, WA, A wholly owned subsidiary of Merck & Co., Inc., Kenilworth, NJ, United States of America
⨯

Intratumoral expression of IL-12 from lentiviral or RNA vectors acts synergistically with TLR4 agonist (GLA) to generate anti-tumor immunological memory

Jardin A. Leleux,
Tina C. Albershardt,
Rebecca Reeves,
Reice James,
Jordan Krull,
Andrea J. Parsons,
Jan ter Meulen,
Peter Berglund

Published: December 2, 2021
https://doi.org/10.1371/journal.pone.0259301

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