Brain-derived neurotrophic factor promotes immune reconstitution following radiation injury via activation of bone marrow mesenchymal stem cells

Guru Prasad Sharma; Anne C. Frei; Jayashree Narayanan; Tracy Gasperetti; Dana Veley; Asma Amjad; Katherine Albano; Brian L. Fish; Heather A. Himburg

doi:10.1371/journal.pone.0259042

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Open Access

Peer-reviewed

Research Article

Brain-derived neurotrophic factor promotes immune reconstitution following radiation injury via activation of bone marrow mesenchymal stem cells

Guru Prasad Sharma,

Roles Data curation, Formal analysis, Methodology, Writing – review & editing

Affiliation Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America

https://orcid.org/0000-0003-3197-4396

⨯
Anne C. Frei,

Roles Data curation, Methodology, Project administration, Resources, Writing – review & editing

Affiliation Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
⨯
Jayashree Narayanan,

Roles Data curation

Affiliation Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
⨯
Tracy Gasperetti,

Roles Data curation

Affiliation Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America

https://orcid.org/0000-0001-9515-0543

⨯
Dana Veley,

Roles Data curation

Affiliation Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
⨯
Asma Amjad,

Roles Methodology

Affiliation Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
⨯
Katherine Albano,

Roles Methodology

Affiliation Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
⨯
Brian L. Fish,

Roles Methodology, Resources, Supervision, Writing – review & editing

Affiliation Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
⨯
Heather A. Himburg

Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

* E-mail: hhimburg@mcw.edu

Affiliations Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America, Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America

https://orcid.org/0000-0002-9676-6371

⨯

Brain-derived neurotrophic factor promotes immune reconstitution following radiation injury via activation of bone marrow mesenchymal stem cells

Guru Prasad Sharma,
Anne C. Frei,
Jayashree Narayanan,
Tracy Gasperetti,
Dana Veley,
Asma Amjad,
Katherine Albano,
Brian L. Fish,
Heather A. Himburg

Published: October 25, 2021
https://doi.org/10.1371/journal.pone.0259042

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Bone marrow cells
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Thymocytes
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Thymus
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Bone marrow
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Musculoskeletal injury
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Radiation therapy
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Regeneration
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Stem cells
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