TRPV4 is activated by mechanical stimulation to induce prostaglandins release in trabecular meshwork, lowering intraocular pressure

• Takatoshi Uchida,

  Roles Conceptualization, Data curation, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Department of Ophthalmology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan, Senju Laboratory of Ocular Science, Senju Pharmaceutical Co., Ltd., Kobe, Japan

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• Shota Shimizu,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliations Department of Ophthalmology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan, Senju Laboratory of Ocular Science, Senju Pharmaceutical Co., Ltd., Kobe, Japan

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• Reiko Yamagishi,

  Roles Data curation, Funding acquisition, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Ophthalmology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan

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• Suzumi M. Tokuoka,

  Roles Data curation, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Lipidomics, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan

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• Yoshihiro Kita,

  Roles Methodology, Software, Writing – review & editing

  Affiliations Department of Lipidomics, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan, Life Science Core Facility, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan

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• Rei Sakata,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliation Department of Ophthalmology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan

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• Megumi Honjo,

  Roles Conceptualization, Methodology, Project administration, Writing – review & editing

  Affiliation Department of Ophthalmology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan

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• Makoto Aihara

  Roles Conceptualization, Project administration, Supervision, Writing – review & editing

  * E-mail: aihara-tky@umin.net

  Affiliation Department of Ophthalmology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan

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