BCG vaccination induces enhanced frequencies of memory T cells and altered plasma levels of common γc cytokines in elderly individuals

Nathella Pavan Kumar; Chandrasekaran Padmapriyadarsini; Anuradha Rajamanickam; Perumal Kannabiran Bhavani; Arul Nancy; Bharathi Jayadeepa; Nandhini Selvaraj; Dinesh Asokan; Rachel Mariam Renji; Vijayalakshmi Venkataramani; Srikanth Tripathy; Subash Babu

doi:10.1371/journal.pone.0258743

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Open Access

Peer-reviewed

Research Article

BCG vaccination induces enhanced frequencies of memory T cells and altered plasma levels of common γc cytokines in elderly individuals

Nathella Pavan Kumar ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

* E-mail: pavankumarn@nirt.res.in (NPK); sbabu@nirt.res.in (SB)

Affiliation ICMR-National Institute for Research in Tuberculosis-International Center for Excellence in Research, Chennai, India

https://orcid.org/0000-0003-2969-2621

⨯
Chandrasekaran Padmapriyadarsini,

Roles Conceptualization, Data curation, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

Affiliation ICMR-National Institute for Research in Tuberculosis-International Center for Excellence in Research, Chennai, India
⨯
Anuradha Rajamanickam,

Roles Formal analysis, Investigation, Methodology

Affiliation ICMR-National Institute for Research in Tuberculosis, Chennai, India
⨯
Perumal Kannabiran Bhavani,

Roles Conceptualization, Project administration, Supervision

Affiliation ICMR-National Institute for Research in Tuberculosis-International Center for Excellence in Research, Chennai, India
⨯
Arul Nancy,

Roles Investigation, Methodology

Affiliation ICMR-National Institute for Research in Tuberculosis, Chennai, India
⨯
Bharathi Jayadeepa,

Roles Data curation, Project administration, Supervision

Affiliation ICMR-National Institute for Research in Tuberculosis-International Center for Excellence in Research, Chennai, India
⨯
Nandhini Selvaraj,

Roles Investigation, Methodology

Affiliation ICMR-National Institute for Research in Tuberculosis, Chennai, India
⨯
Dinesh Asokan,

Roles Data curation, Project administration, Supervision

Affiliation ICMR-National Institute for Research in Tuberculosis-International Center for Excellence in Research, Chennai, India
⨯
Rachel Mariam Renji,

Roles Investigation, Methodology

Affiliation ICMR-National Institute for Research in Tuberculosis, Chennai, India
⨯
Vijayalakshmi Venkataramani,

Roles Investigation, Methodology

Affiliation ICMR-National Institute for Research in Tuberculosis, Chennai, India
⨯
Srikanth Tripathy,

Roles Conceptualization, Data curation, Funding acquisition, Project administration, Supervision

Affiliations ICMR-National Institute for Research in Tuberculosis-International Center for Excellence in Research, Chennai, India, Dr D Y Patil Medical College, Hospital and Research Centre, Pune, India
⨯
Subash Babu

Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

* E-mail: pavankumarn@nirt.res.in (NPK); sbabu@nirt.res.in (SB)

Affiliation ICMR-National Institute for Research in Tuberculosis, Chennai, India
⨯

BCG vaccination induces enhanced frequencies of memory T cells and altered plasma levels of common γc cytokines in elderly individuals

Nathella Pavan Kumar,
Chandrasekaran Padmapriyadarsini,
Anuradha Rajamanickam,
Perumal Kannabiran Bhavani,
Arul Nancy,
Bharathi Jayadeepa,
Nandhini Selvaraj,
Dinesh Asokan,
Rachel Mariam Renji,
Vijayalakshmi Venkataramani

Published: November 10, 2021
https://doi.org/10.1371/journal.pone.0258743

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Vaccination and immunization
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Cytotoxic T cells
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Cytokines
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Memory T cells
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Respiratory infections
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Elderly
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HIV vaccines
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