Molecular dynamics and protein frustration analysis of human fused in Sarcoma protein variants in Amyotrophic Lateral Sclerosis type 6: An In Silico approach

L. F. S. Bonet; J. P. Loureiro; G. R. C. Pereira; A. N. R. Da Silva; J. F. De Mesquita

doi:10.1371/journal.pone.0258061

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Peer-reviewed

Research Article

Molecular dynamics and protein frustration analysis of human fused in Sarcoma protein variants in Amyotrophic Lateral Sclerosis type 6: An In Silico approach

L. F. S. Bonet,

Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Genetics and Molecular Biology, Laboratory of Bioinformatics and Computational Biology, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil

https://orcid.org/0000-0002-0435-4469

⨯
J. P. Loureiro,

Roles Formal analysis, Investigation, Methodology

Affiliation Department of Genetics and Molecular Biology, Laboratory of Bioinformatics and Computational Biology, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil
⨯
G. R. C. Pereira,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Genetics and Molecular Biology, Laboratory of Bioinformatics and Computational Biology, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil
⨯
A. N. R. Da Silva,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Genetics and Molecular Biology, Laboratory of Bioinformatics and Computational Biology, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil

https://orcid.org/0000-0002-7559-3635

⨯
J. F. De Mesquita

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: joelma.mesquita@unirio.br

Affiliation Department of Genetics and Molecular Biology, Laboratory of Bioinformatics and Computational Biology, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil

https://orcid.org/0000-0003-1684-3830

⨯

Molecular dynamics and protein frustration analysis of human fused in Sarcoma protein variants in Amyotrophic Lateral Sclerosis type 6: An In Silico approach

L. F. S. Bonet,
J. P. Loureiro,
G. R. C. Pereira,
A. N. R. Da Silva,
J. F. De Mesquita

Published: September 29, 2021
https://doi.org/10.1371/journal.pone.0258061

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Amyotrophic lateral sclerosis
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Molecular dynamics
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Algorithms
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Amino acid analysis
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Deletion mutation
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Mutation
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Biochemical simulations
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Protein structure
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