SGLT2 inhibitors therapy protects glucotoxicity-induced β-cell failure in a mouse model of human KATP-induced diabetes through mitigation of oxidative and ER stress

Zeenat A. Shyr; Zihan Yan; Alessandro Ustione; Erin M. Egan; Maria S. Remedi

doi:10.1371/journal.pone.0258054

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Peer-reviewed

Research Article

SGLT2 inhibitors therapy protects glucotoxicity-induced β-cell failure in a mouse model of human K_ATP-induced diabetes through mitigation of oxidative and ER stress

Zeenat A. Shyr,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

Affiliations Division of Endocrinology, Metabolism and Lipid Research, Department of Medicine, Washington University in St. Louis, St. Louis, Missouri, United States of America, Center for the Investigation of Membrane Excitability Diseases, Washington University in St. Louis, St. Louis, Missouri, United States of America
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Zihan Yan,

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliations Division of Endocrinology, Metabolism and Lipid Research, Department of Medicine, Washington University in St. Louis, St. Louis, Missouri, United States of America, Center for the Investigation of Membrane Excitability Diseases, Washington University in St. Louis, St. Louis, Missouri, United States of America
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Alessandro Ustione,

Roles Data curation, Formal analysis, Methodology

Affiliation Department of Cell Biology and Physiology, Washington University in St. Louis, St. Louis, Missouri, United States of America
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Erin M. Egan,

Roles Data curation, Formal analysis

Affiliation Division of Endocrinology, Metabolism and Lipid Research, Department of Medicine, Washington University in St. Louis, St. Louis, Missouri, United States of America
⨯
Maria S. Remedi

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Supervision, Writing – review & editing

* E-mail: mremedi@wustl.edu

Affiliations Division of Endocrinology, Metabolism and Lipid Research, Department of Medicine, Washington University in St. Louis, St. Louis, Missouri, United States of America, Center for the Investigation of Membrane Excitability Diseases, Washington University in St. Louis, St. Louis, Missouri, United States of America, Department of Cell Biology and Physiology, Washington University in St. Louis, St. Louis, Missouri, United States of America

https://orcid.org/0000-0003-2048-472X

⨯

SGLT2 inhibitors therapy protects glucotoxicity-induced β-cell failure in a mouse model of human K_ATP-induced diabetes through mitigation of oxidative and ER stress

Zeenat A. Shyr,
Zihan Yan,
Alessandro Ustione,
Erin M. Egan,
Maria S. Remedi

Published: February 18, 2022
https://doi.org/10.1371/journal.pone.0258054

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