Direct administration of the non-competitive interleukin-1 receptor antagonist rytvela transiently reduced intrauterine inflammation in an extremely preterm sheep model of chorioamnionitis

• Yuki Takahashi ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing

  * E-mail: yuki.sakurai@uwa.edu.au

  Affiliations Division of Obstetrics and Gynecology, The University of Western Australia, Perth, Western Australia, Australia, Centre for Perinatal and Neonatal Medicine, Tohoku University Hospital, Sendai, Japan

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• Masatoshi Saito,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Division of Obstetrics and Gynecology, The University of Western Australia, Perth, Western Australia, Australia, Centre for Perinatal and Neonatal Medicine, Tohoku University Hospital, Sendai, Japan

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• Haruo Usuda,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Supervision, Writing – review & editing

  Affiliation Division of Obstetrics and Gynecology, The University of Western Australia, Perth, Western Australia, Australia

  ⨯
• Tsukasa Takahashi,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Division of Obstetrics and Gynecology, The University of Western Australia, Perth, Western Australia, Australia, Centre for Perinatal and Neonatal Medicine, Tohoku University Hospital, Sendai, Japan

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• Shimpei Watanabe,

  Roles Investigation, Methodology, Supervision, Writing – review & editing

  Affiliation Centre for Perinatal and Neonatal Medicine, Tohoku University Hospital, Sendai, Japan

  ⨯
• Takushi Hanita,

  Roles Investigation, Methodology, Supervision, Writing – review & editing

  Affiliation Centre for Perinatal and Neonatal Medicine, Tohoku University Hospital, Sendai, Japan

  ⨯
• Shinichi Sato,

  Roles Investigation, Methodology, Supervision, Writing – review & editing

  Affiliation Centre for Perinatal and Neonatal Medicine, Tohoku University Hospital, Sendai, Japan

  ⨯
• Yusaku Kumagai,

  Roles Investigation, Methodology, Supervision, Writing – review & editing

  Affiliation Centre for Perinatal and Neonatal Medicine, Tohoku University Hospital, Sendai, Japan

  https://orcid.org/0000-0003-3253-9601

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• Shota Koshinami,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Centre for Perinatal and Neonatal Medicine, Tohoku University Hospital, Sendai, Japan

  ⨯
• Hideyuki Ikeda,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Centre for Perinatal and Neonatal Medicine, Tohoku University Hospital, Sendai, Japan

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• Sean Carter,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Division of Obstetrics and Gynecology, The University of Western Australia, Perth, Western Australia, Australia

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• Erin L. Fee,

  Roles Conceptualization, Investigation, Methodology, Project administration, Writing – review & editing

  Affiliation Division of Obstetrics and Gynecology, The University of Western Australia, Perth, Western Australia, Australia

  ⨯
• Lucy Furfaro,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Division of Obstetrics and Gynecology, The University of Western Australia, Perth, Western Australia, Australia

  ⨯
• Sylvain Chemtob,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Pharmacology and Physiology, University of Montreal, Montreal, Canada

  ⨯
• Jeffrey Keelan,

  Roles Conceptualization, Funding acquisition, Project administration, Writing – review & editing

  Affiliation Division of Obstetrics and Gynecology, The University of Western Australia, Perth, Western Australia, Australia

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• David Olson,

  Roles Conceptualization, Funding acquisition, Project administration, Writing – review & editing

  Affiliation Department of Obstetrics and Gynaecology, University of Alberta, Alberta, Canada

  ⨯
• Nobuo Yaegashi,

  Roles Supervision, Writing – review & editing

  Affiliation Centre for Perinatal and Neonatal Medicine, Tohoku University Hospital, Sendai, Japan

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• John P. Newnham,

  Roles Conceptualization, Methodology, Supervision, Writing – review & editing

  Affiliation Division of Obstetrics and Gynecology, The University of Western Australia, Perth, Western Australia, Australia

  ⨯
• Alan H. Jobe,

  Roles Investigation, Project administration, Supervision, Writing – review & editing

  Affiliations Division of Obstetrics and Gynecology, The University of Western Australia, Perth, Western Australia, Australia, Cincinnati Children’s Hospital Medical Centre, Cincinnati, OH, United States of America

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•  [ ... ],
• Matthew W. Kemp

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Division of Obstetrics and Gynecology, The University of Western Australia, Perth, Western Australia, Australia, Centre for Perinatal and Neonatal Medicine, Tohoku University Hospital, Sendai, Japan, School of Veterinary and Life Sciences, Murdoch University, Perth, Western Australia, Australia, Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

  https://orcid.org/0000-0001-9662-5029

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