Applying historical data in a nonlinear mixed-effects model can reduce the number of control rats required for calculation of the relative potency of insulin analogues

• Emilie Prang Nielsen ,

  Contributed equally to this work with: Emilie Prang Nielsen, Søren Andersen, Christian Lehn Brand, Susanne Ditlevsen

  Roles Formal analysis, Investigation, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: emilie.nielsen@hotmail.com

  Affiliation Biostatistics, Novo Nordisk A/S, Søborg, Denmark

  https://orcid.org/0000-0002-4544-1972

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• Søren Andersen ,

  Contributed equally to this work with: Emilie Prang Nielsen, Søren Andersen, Christian Lehn Brand, Susanne Ditlevsen

  Roles Conceptualization, Methodology, Supervision, Writing – review & editing

  Affiliation Biostatistics, Novo Nordisk A/S, Søborg, Denmark

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• Christian Lehn Brand ,

  Contributed equally to this work with: Emilie Prang Nielsen, Søren Andersen, Christian Lehn Brand, Susanne Ditlevsen

  Roles Data curation, Project administration, Writing – review & editing

  Affiliation Diabetes Pharmacology, Novo Nordisk A/S, Måløv, Denmark

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• Susanne Ditlevsen

  Contributed equally to this work with: Emilie Prang Nielsen, Søren Andersen, Christian Lehn Brand, Susanne Ditlevsen

  Roles Methodology, Supervision, Writing – review & editing

  Affiliation Data Science Laboratory, University of Copenhagen, Copenhagen, Denmark

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