Targeting anaplastic lymphoma kinase (ALK) gene alterations in neuroblastoma by using alkylating pyrrole-imidazole polyamides

Yoko Ota; Hiroyuki Yoda; Takahiro Inoue; Takayoshi Watanabe; Yoshinao Shinozaki; Atsushi Takatori; Hiroki Nagase

doi:10.1371/journal.pone.0257718

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Open Access

Peer-reviewed

Research Article

Targeting anaplastic lymphoma kinase (ALK) gene alterations in neuroblastoma by using alkylating pyrrole-imidazole polyamides

Yoko Ota,

Roles Formal analysis, Funding acquisition, Investigation, Writing – original draft

Affiliations Division of Innovative Cancer Therapeutics, Chiba Cancer Center Research Institute, Chiba, Japan, Graduate School of Medical and Pharmaceutical Sciences, Chiba University, Chiba, Japan
⨯
Hiroyuki Yoda,

Roles Formal analysis, Investigation

Affiliations Division of Innovative Cancer Therapeutics, Chiba Cancer Center Research Institute, Chiba, Japan, Division of Cancer Genetics, Chiba Cancer Center Research Institute, Chiba, Japan

https://orcid.org/0000-0002-5528-8940

⨯
Takahiro Inoue,

Roles Formal analysis, Investigation

Affiliations Graduate School of Medical and Pharmaceutical Sciences, Chiba University, Chiba, Japan, Division of Cancer Genetics, Chiba Cancer Center Research Institute, Chiba, Japan
⨯
Takayoshi Watanabe,

Roles Formal analysis, Investigation

Affiliation Division of Innovative Cancer Therapeutics, Chiba Cancer Center Research Institute, Chiba, Japan
⨯
Yoshinao Shinozaki,

Roles Formal analysis, Investigation

Affiliation Division of Cancer Genetics, Chiba Cancer Center Research Institute, Chiba, Japan
⨯
Atsushi Takatori ,

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – review & editing

* E-mail: atakatori@chiba-cc.jp (AT); hnagase@chiba-cc.jp (HN)

Affiliation Division of Innovative Cancer Therapeutics, Chiba Cancer Center Research Institute, Chiba, Japan

https://orcid.org/0000-0002-2184-6721

⨯
Hiroki Nagase

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Writing – review & editing

* E-mail: atakatori@chiba-cc.jp (AT); hnagase@chiba-cc.jp (HN)

Affiliations Graduate School of Medical and Pharmaceutical Sciences, Chiba University, Chiba, Japan, Division of Cancer Genetics, Chiba Cancer Center Research Institute, Chiba, Japan
⨯

Targeting anaplastic lymphoma kinase (ALK) gene alterations in neuroblastoma by using alkylating pyrrole-imidazole polyamides

Yoko Ota,
Hiroyuki Yoda,
Takahiro Inoue,
Takayoshi Watanabe,
Yoshinao Shinozaki,
Atsushi Takatori,
Hiroki Nagase

Published: September 30, 2021
https://doi.org/10.1371/journal.pone.0257718

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Neuroblastoma
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Neuroblastoma cells
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Cancers and neoplasms
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Point mutation
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Liquid chromatography-mass spectrometry
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Oligonucleotides
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