The inhibitory effects of toothpaste and mouthwash ingredients on the interaction between the SARS-CoV-2 spike protein and ACE2, and the protease activity of TMPRSS2 in vitro

• Riho Tateyama-Makino ,

  Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

  * E-mail: riho-t@lion.co.jp

  ¶‡ These authors have contributed equally to this work and share first authorship

  Affiliation Research & Development Headquarters, Lion Corporation, Edogawa-ku, Tokyo, Japan

  https://orcid.org/0000-0001-5206-8339

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• Mari Abe-Yutori ,

  Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

  ¶‡ These authors have contributed equally to this work and share first authorship

  Affiliation Research & Development Headquarters, Lion Corporation, Edogawa-ku, Tokyo, Japan

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• Taku Iwamoto,

  Roles Conceptualization, Methodology, Visualization, Writing – original draft

  Affiliation Research & Development Headquarters, Lion Corporation, Edogawa-ku, Tokyo, Japan

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• Kota Tsutsumi,

  Roles Conceptualization, Methodology, Visualization, Writing – original draft

  Affiliation Research & Development Headquarters, Lion Corporation, Edogawa-ku, Tokyo, Japan

  https://orcid.org/0000-0003-1371-2915

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• Motonori Tsuji,

  Roles Investigation, Methodology, Software, Validation, Visualization, Writing – original draft

  Affiliation Institute of Molecular Function, Misato-shi, Saitama, Japan

  https://orcid.org/0000-0003-0734-0334

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• Satoru Morishita,

  Roles Conceptualization, Writing – review & editing

  Affiliation Research & Development Headquarters, Lion Corporation, Edogawa-ku, Tokyo, Japan

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• Kei Kurita,

  Roles Conceptualization, Writing – review & editing

  Affiliation Research & Development Headquarters, Lion Corporation, Edogawa-ku, Tokyo, Japan

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• Yukio Yamamoto,

  Roles Conceptualization, Funding acquisition, Project administration, Writing – review & editing

  Affiliation Research & Development Headquarters, Lion Corporation, Edogawa-ku, Tokyo, Japan

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• Eiji Nishinaga,

  Roles Conceptualization, Funding acquisition, Project administration, Writing – review & editing

  Affiliation Research & Development Headquarters, Lion Corporation, Edogawa-ku, Tokyo, Japan

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• Keiichi Tsukinoki

  Roles Conceptualization, Supervision, Writing – review & editing

  Affiliation Division of Environmental Pathology, Department of Oral Science, Kanagawa Dental University, Yokosuka, Kanagawa, Japan

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