Somatostatin analog therapy effectiveness on the progression of polycystic kidney and liver disease: A systematic review and meta-analysis of randomized clinical trials

Tatsuya Suwabe; Francisco J. Barrera; Rene Rodriguez-Gutierrez; Yoshifumi Ubara; Marie C. Hogan

doi:10.1371/journal.pone.0257606

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Open Access

Peer-reviewed

Research Article

Somatostatin analog therapy effectiveness on the progression of polycystic kidney and liver disease: A systematic review and meta-analysis of randomized clinical trials

Tatsuya Suwabe ,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – original draft

* E-mail: suwabetat@gmail.com

Affiliations Division of Nephrology, Toranomon Hospital, Tokyo, Japan, Okinaka Memorial Institute for Medical Research, Toranomon Hospital, Tokyo, Japan

https://orcid.org/0000-0003-0825-2512

⨯
Francisco J. Barrera,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – review & editing

Affiliations Plataforma INVEST Medicina UANL KER Unit Mayo Clinic, KER Unit México, Medical School and University Hospital “Dr. Jose E. Gonzalez”, Universidad Autonoma de Nuevo Leon, Monterrey, Mexico, Knowledge and Evaluation Research Unit in Endocrinology (KER-Endo), Mayo Clinic, Rochester, MN, United States of America
⨯
Rene Rodriguez-Gutierrez,

Roles Supervision, Validation, Visualization, Writing – review & editing

Affiliations Plataforma INVEST Medicina UANL KER Unit Mayo Clinic, KER Unit México, Medical School and University Hospital “Dr. Jose E. Gonzalez”, Universidad Autonoma de Nuevo Leon, Monterrey, Mexico, Knowledge and Evaluation Research Unit in Endocrinology (KER-Endo), Mayo Clinic, Rochester, MN, United States of America
⨯
Yoshifumi Ubara,

Roles Supervision, Visualization, Writing – review & editing

Affiliations Division of Nephrology, Toranomon Hospital, Tokyo, Japan, Okinaka Memorial Institute for Medical Research, Toranomon Hospital, Tokyo, Japan
⨯
Marie C. Hogan

Roles Supervision, Validation, Visualization, Writing – review & editing

Affiliation Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, United States of America
⨯

Somatostatin analog therapy effectiveness on the progression of polycystic kidney and liver disease: A systematic review and meta-analysis of randomized clinical trials

Tatsuya Suwabe,
Francisco J. Barrera,
Rene Rodriguez-Gutierrez,
Yoshifumi Ubara,
Marie C. Hogan

Published: September 24, 2021
https://doi.org/10.1371/journal.pone.0257606

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Somatostatin
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Metaanalysis
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Randomized controlled trials
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Adverse events
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Kidneys
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Medical risk factors
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Glomerular filtration rate
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Liver diseases
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