Roadmap for the use of base editors to decipher drug mechanism of action

Estel Aparicio-Prat; Dong Yan; Marco Mariotti; Michael Bassik; Gaelen Hess; Jean-Philippe Fortin; Andrea Weston; Hualin S. Xi; Robert Stanton

doi:10.1371/journal.pone.0257537

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Open Access

Peer-reviewed

Research Article

Roadmap for the use of base editors to decipher drug mechanism of action

Estel Aparicio-Prat ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: estelaparicio@gmail.com (EAP); robert.stanton@pfizer.com (RS)

Affiliation Simulation and Modelling Sciences, Pfizer, Cambridge, Massachusetts, United States of America

https://orcid.org/0000-0003-4477-5839

⨯
Dong Yan,

Roles Investigation, Writing – review & editing

Affiliation Internal Medicine Research Unit, Pfizer, Cambridge, Massachusetts, United States of America
⨯
Marco Mariotti,

Roles Formal analysis, Visualization, Writing – review & editing

Affiliations Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Facultat de Biologia, Departament de Genètica, Microbiologia i Estadística, Universitat de Barcelona, Barcelona, Catalonia, Spain
⨯
Michael Bassik,

Roles Methodology

Affiliation Department of Genetics, Stanford University, Palo Alto, California, United States of America
⨯
Gaelen Hess,

Roles Methodology

Affiliation Department of Genetics, Stanford University, Palo Alto, California, United States of America
⨯
Jean-Philippe Fortin,

Roles Supervision, Writing – review & editing

Affiliation Internal Medicine Research Unit, Pfizer, Cambridge, Massachusetts, United States of America
⨯
Andrea Weston,

Roles Supervision, Writing – review & editing

Affiliation Discovery Sciences, Pfizer, Groton, Connecticut, United States of America
⨯
Hualin S. Xi,

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation Simulation and Modelling Sciences, Pfizer, Cambridge, Massachusetts, United States of America
⨯
Robert Stanton

Roles Formal analysis, Supervision, Writing – review & editing

* E-mail: estelaparicio@gmail.com (EAP); robert.stanton@pfizer.com (RS)

Affiliation Simulation and Modelling Sciences, Pfizer, Cambridge, Massachusetts, United States of America
⨯

Roadmap for the use of base editors to decipher drug mechanism of action

Estel Aparicio-Prat,
Dong Yan,
Marco Mariotti,
Michael Bassik,
Gaelen Hess,
Jean-Philippe Fortin,
Andrea Weston,
Hualin S. Xi,
Robert Stanton

Published: September 21, 2021
https://doi.org/10.1371/journal.pone.0257537

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