Dabrafenib, idelalisib and nintedanib act as significant allosteric modulator for dengue NS3 protease

R. V. Sriram Uday; Rajdip Misra; Annaram Harika; Sandip Dolui; Achintya Saha; Uttam Pal; V. Ravichandiran; Nakul C. Maiti

doi:10.1371/journal.pone.0257206

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Open Access

Peer-reviewed

Research Article

Dabrafenib, idelalisib and nintedanib act as significant allosteric modulator for dengue NS3 protease

R. V. Sriram Uday ,

Contributed equally to this work with: R. V. Sriram Uday, Rajdip Misra

Roles Data curation, Methodology, Software, Validation

Affiliation National Institute of Pharmaceutical Education and Research, Kolkata, Chunilal Bhawan, Kolkata, West Bengal, India
⨯
Rajdip Misra ,

Contributed equally to this work with: R. V. Sriram Uday, Rajdip Misra

Roles Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation Structural Biology and Bioinformatics Division, Indian Institute of Chemical Biology, Council of Scientific and Industrial Research, Kolkata, West Bengal, India
⨯
Annaram Harika,

Roles Methodology, Software

Affiliation National Institute of Pharmaceutical Education and Research, Kolkata, Chunilal Bhawan, Kolkata, West Bengal, India
⨯
Sandip Dolui,

Roles Software, Validation

Affiliation Structural Biology and Bioinformatics Division, Indian Institute of Chemical Biology, Council of Scientific and Industrial Research, Kolkata, West Bengal, India
⨯
Achintya Saha,

Roles Conceptualization, Validation

Affiliation Department of Chemical Technology, University of Calcutta, Kolkata, West Bengal, India
⨯
Uttam Pal ,

Roles Conceptualization, Validation, Writing – review & editing

* E-mail: ncmaiti@iicb.res.in (NCM); director@niperkolkata.edu.in (VR); uttam2707@gmail.com (UP)

Current address: S.N. Bose National Centre for Basic Sciences, Salt Lake City, Kolkata, West Bengal, India

Affiliation Structural Biology and Bioinformatics Division, Indian Institute of Chemical Biology, Council of Scientific and Industrial Research, Kolkata, West Bengal, India

https://orcid.org/0000-0003-2110-4610

⨯
V. Ravichandiran ,

Roles Conceptualization, Validation

* E-mail: ncmaiti@iicb.res.in (NCM); director@niperkolkata.edu.in (VR); uttam2707@gmail.com (UP)

Affiliation National Institute of Pharmaceutical Education and Research, Kolkata, Chunilal Bhawan, Kolkata, West Bengal, India
⨯
Nakul C. Maiti

Roles Conceptualization, Investigation, Supervision, Writing – original draft, Writing – review & editing

* E-mail: ncmaiti@iicb.res.in (NCM); director@niperkolkata.edu.in (VR); uttam2707@gmail.com (UP)

Affiliation Structural Biology and Bioinformatics Division, Indian Institute of Chemical Biology, Council of Scientific and Industrial Research, Kolkata, West Bengal, India

https://orcid.org/0000-0002-8498-6502

⨯

Dabrafenib, idelalisib and nintedanib act as significant allosteric modulator for dengue NS3 protease

R. V. Sriram Uday,
Rajdip Misra,
Annaram Harika,
Sandip Dolui,
Achintya Saha,
Uttam Pal,
V. Ravichandiran,
Nakul C. Maiti

Published: September 10, 2021
https://doi.org/10.1371/journal.pone.0257206

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