Uricase deficiency causes mild and multiple organ injuries in rats

Nan Fan; Yun Yu; Lvyu Li; Heng Xia; Xiangxian Dong; Yongkun Li; Huan Chen; Weigang Duan

doi:10.1371/journal.pone.0256594

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Open Access

Peer-reviewed

Research Article

Uricase deficiency causes mild and multiple organ injuries in rats

Nan Fan ,

Contributed equally to this work with: Nan Fan, Yun Yu

Roles Formal analysis, Investigation, Methodology, Resources, Writing – original draft

Affiliation The Department of Pharmacology, School of Basic Medicine, Kunming Medical University, Kunming, Yunnan Province, China
⨯
Yun Yu ,

Contributed equally to this work with: Nan Fan, Yun Yu

Roles Funding acquisition, Resources, Software, Supervision

Affiliation The Department of Pharmacology, School of Basic Medicine, Kunming Medical University, Kunming, Yunnan Province, China
⨯
Lvyu Li,

Roles Funding acquisition, Project administration, Supervision, Writing – original draft

Affiliation The Third Affiliated Hospital, Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan Province, China
⨯
Heng Xia,

Roles Formal analysis, Investigation, Methodology

Affiliation Yunnan Provincial Key Laboratory of Molecular Biology for Sinomedicine, School of Basic Medicine, Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan Province, China
⨯
Xiangxian Dong,

Roles Investigation, Methodology

Affiliation The Department of Pharmacology, School of Basic Medicine, Kunming Medical University, Kunming, Yunnan Province, China

https://orcid.org/0000-0003-2554-5704

⨯
Yongkun Li,

Roles Methodology, Visualization

Affiliation Yunnan Provincial Key Laboratory of Molecular Biology for Sinomedicine, School of Basic Medicine, Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan Province, China
⨯
Huan Chen,

Roles Methodology, Supervision, Visualization

Affiliation Yunnan Provincial Key Laboratory of Molecular Biology for Sinomedicine, School of Basic Medicine, Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan Province, China
⨯
Weigang Duan

Roles Conceptualization, Data curation, Formal analysis, Project administration, Supervision, Writing – review & editing

* E-mail: deardwg@126.com

Affiliation Yunnan Provincial Key Laboratory of Molecular Biology for Sinomedicine, School of Basic Medicine, Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan Province, China

https://orcid.org/0000-0002-9006-861X

⨯

Uricase deficiency causes mild and multiple organ injuries in rats

Nan Fan,
Yun Yu,
Lvyu Li,
Heng Xia,
Xiangxian Dong,
Yongkun Li,
Huan Chen,
Weigang Duan

Published: August 26, 2021
https://doi.org/10.1371/journal.pone.0256594

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