High-throughput kinome-RNAi screen identifies protein kinase R activator (PACT) as a novel genetic modifier of CUG foci integrity in myotonic dystrophy type 1 (DM1)

• Nafisa Neault ,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: mackenzie@cheo.on.ca (AM); ntasn064@uottawa.ca (NN)

  Affiliations Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada, Children’s Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada

  https://orcid.org/0000-0002-6870-6013

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• Sean O’Reilly,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Software, Validation, Visualization, Writing – original draft

  Affiliations Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada, Children’s Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada

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• Aiman Tariq Baig,

  Roles Data curation, Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliations Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada, Children’s Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada

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• Julio Plaza-Diaz,

  Roles Investigation, Methodology

  Affiliation Children’s Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada

  https://orcid.org/0000-0002-5171-9408

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• Mehrdad Azimi,

  Roles Data curation, Methodology, Validation, Writing – review & editing

  Affiliations Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada, Children’s Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada

  https://orcid.org/0000-0002-2263-8422

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• Faraz Farooq,

  Roles Supervision, Writing – review & editing

  Affiliations Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada, Children’s Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada

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• Stephen D. Baird,

  Roles Data curation, Methodology, Resources, Software, Supervision, Writing – review & editing

  Affiliation Children’s Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada

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• Alex MacKenzie

  Roles Conceptualization, Funding acquisition, Investigation, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: mackenzie@cheo.on.ca (AM); ntasn064@uottawa.ca (NN)

  Affiliations Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada, Children’s Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada

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