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The orphan drug dichloroacetate reduces amyloid beta-peptide production whilst promoting non-amyloidogenic proteolysis of the amyloid precursor protein
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Edward T. Parkin ,
Contributed equally to this work with: Edward T. Parkin, Jessica E. Hammond
Roles Conceptualization, Methodology, Writing – original draft, Writing – review & editing
* E-mail: e.parkin@lancaster.ac.uk
Affiliation Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster, United Kingdom
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Jessica E. Hammond ,
Contributed equally to this work with: Edward T. Parkin, Jessica E. Hammond
Roles Formal analysis, Investigation
Affiliation Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster, United Kingdom
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Lauren Owens,
Roles Investigation
Affiliation Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster, United Kingdom
⨯ - Matthew D. Hodges
https://orcid.org/0000-0003-3270-3184
The orphan drug dichloroacetate reduces amyloid beta-peptide production whilst promoting non-amyloidogenic proteolysis of the amyloid precursor protein
- Edward T. Parkin,
- Jessica E. Hammond,
- Lauren Owens,
- Matthew D. Hodges
- Published: January 13, 2022
- https://doi.org/10.1371/journal.pone.0255715
- See the preprint