Low-level overexpression of wild type TDP-43 causes late-onset, progressive neurodegeneration and paralysis in mice

• Chunxing Yang,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft

  Current address: CoWin Biosciences, Shrewsbury, MA, United States of America

  Affiliation Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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• Tao Qiao,

  Roles Formal analysis, Investigation, Methodology, Validation, Visualization

  Current address: Astellas Pharma, Marlborough, MA, United States of America

  Affiliation Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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• Jia Yu,

  Roles Formal analysis, Investigation, Methodology, Validation, Visualization

  Current address: Institute for Geriatrics and Rehabilitation, Beijing Geriatric Hospital, Haidian District, Beijing, China

  Affiliation Transgenics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, United States of America

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• Hongyan Wang,

  Roles Formal analysis, Investigation, Methodology, Validation, Visualization

  Affiliation Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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• Yansu Guo,

  Roles Formal analysis, Funding acquisition, Investigation, Methodology, Validation, Visualization

  Current address: Beijing Geriatric Healthcare Center, Xuanwu Hospital, Capital Medical University, Xicheng, Beijing, China

  Affiliation Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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• Johnny Salameh,

  Roles Formal analysis, Investigation, Methodology, Validation

  Current address: Department of Neurology, American University Beirut Medical Center (AUBMC), Beirut, Lebanon

  Affiliation Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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• Jake Metterville,

  Roles Formal analysis, Investigation, Methodology, Validation

  Affiliation Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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• Sepideh Parsi,

  Roles Formal analysis, Visualization

  Affiliation Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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• Issa Yusuf,

  Roles Investigation

  Affiliation Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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• Robert H. Brown,

  Roles Funding acquisition, Resources, Supervision, Writing – review & editing

  Affiliations Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, RNA Therapeutic Institute, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, Neuroscience Program, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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• Huaibin Cai,

  Roles Funding acquisition, Methodology, Resources, Supervision

  Affiliation Transgenics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, United States of America

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• Zuoshang Xu

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: Zuoshang.xu@umassmed.edu

  Affiliations Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, RNA Therapeutic Institute, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America, Neuroscience Program, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

  https://orcid.org/0000-0003-1209-334X

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