A structure-based engineering approach to abrogate pre-existing antibody binding to biotherapeutics

• Joanne Lin,

  Roles Investigation, Methodology, Visualization, Writing – review & editing

  Affiliation Eli Lilly & Co, Lilly Biotechnology Center, San Diego, California, United States of America

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• Stacey L. Lee,

  Roles Investigation, Visualization, Writing – review & editing

  Affiliation Eli Lilly & Co, Lilly Biotechnology Center, San Diego, California, United States of America

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• Anna M. Russell,

  Roles Formal analysis, Investigation, Visualization, Writing – review & editing

  Affiliation Eli Lilly & Co, Lilly Biotechnology Center, San Diego, California, United States of America

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• Rong Fong Huang,

  Roles Investigation, Writing – review & editing

  Affiliation Eli Lilly & Co, Lilly Biotechnology Center, San Diego, California, United States of America

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• Micheal A. Batt,

  Roles Investigation, Writing – review & editing

  Affiliation Eli Lilly & Co, Lilly Biotechnology Center, San Diego, California, United States of America

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• Shawn S. Chang,

  Roles Investigation, Visualization, Writing – review & editing

  Affiliation Eli Lilly & Co, Lilly Biotechnology Center, San Diego, California, United States of America

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• Andrea Ferrante,

  Roles Conceptualization, Investigation, Supervision, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Eli Lilly & Co, Lilly Biotechnology Center, San Diego, California, United States of America

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• Petra Verdino

  Roles Conceptualization, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: verdino_petra@lilly.com

  Affiliation Eli Lilly & Co, Lilly Biotechnology Center, San Diego, California, United States of America

  https://orcid.org/0000-0002-4914-0659

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