Norcycloartocarpin targets Akt and suppresses Akt-dependent survival and epithelial-mesenchymal transition in lung cancer cells

Nongyao Nonpanya; Kittipong Sanookpan; Keerati Joyjamras; Duangdao Wichadakul; Boonchoo Sritularak; Chatchai Chaotham; Pithi Chanvorachote

doi:10.1371/journal.pone.0254929

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Open Access

Peer-reviewed

Research Article

Norcycloartocarpin targets Akt and suppresses Akt-dependent survival and epithelial-mesenchymal transition in lung cancer cells

Nongyao Nonpanya,

Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliations Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
⨯
Kittipong Sanookpan,

Roles Methodology, Writing – original draft

Affiliations Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
⨯
Keerati Joyjamras,

Roles Methodology

Affiliations Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand, Graduate Program of Pharmaceutical Sciences and Technology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
⨯
Duangdao Wichadakul,

Roles Writing – original draft

Affiliation Department of Computer Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok, Thailand
⨯
Boonchoo Sritularak,

Roles Resources

Affiliation Departments of Pharmacognosy and Pharmaceutical Botany, Chulalongkorn University, Bangkok, Thailand
⨯
Chatchai Chaotham,

Roles Writing – original draft

Affiliations Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand, Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand

https://orcid.org/0000-0002-3206-192X

⨯
Pithi Chanvorachote

Roles Conceptualization, Data curation, Formal analysis, Project administration, Visualization, Writing – original draft, Writing – review & editing

* E-mail: pithi_chan@yahoo.com

Affiliations Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand

https://orcid.org/0000-0002-3103-3249

⨯

Norcycloartocarpin targets Akt and suppresses Akt-dependent survival and epithelial-mesenchymal transition in lung cancer cells

Nongyao Nonpanya,
Kittipong Sanookpan,
Keerati Joyjamras,
Duangdao Wichadakul,
Boonchoo Sritularak,
Chatchai Chaotham,
Pithi Chanvorachote

Published: August 12, 2021
https://doi.org/10.1371/journal.pone.0254929

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Apoptosis
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