Contrasting functional responses of resident Kupffer cells and recruited liver macrophages to irradiation and liver X receptor stimulation

Takuya Ishikiriyama; Hiroyuki Nakashima; Kaori Endo-Umeda; Masahiro Nakashima; Seigo Ito; Manabu Kinoshita; Masami Ikarashi; Makoto Makishima; Shuhji Seki

doi:10.1371/journal.pone.0254886

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Open Access

Peer-reviewed

Research Article

Contrasting functional responses of resident Kupffer cells and recruited liver macrophages to irradiation and liver X receptor stimulation

Takuya Ishikiriyama,

Roles Investigation, Methodology, Project administration

Affiliation Department of Immunology and Microbiology, National Defense Medical College, Tokorozawa, Saitama, Japan
⨯
Hiroyuki Nakashima ,

Roles Conceptualization, Investigation, Methodology, Supervision, Writing – original draft

* E-mail: hiro1618@ndmc.ac.jp

Affiliation Department of Immunology and Microbiology, National Defense Medical College, Tokorozawa, Saitama, Japan

https://orcid.org/0000-0001-6066-3031

⨯
Kaori Endo-Umeda,

Roles Conceptualization, Investigation, Methodology

Affiliation Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, Itabashi, Tokyo, Japan
⨯
Masahiro Nakashima,

Roles Investigation, Methodology

Affiliation Department of Immunology and Microbiology, National Defense Medical College, Tokorozawa, Saitama, Japan
⨯
Seigo Ito,

Roles Investigation, Methodology

Affiliation Department of Nephrology and Endocrinology, National Defense Medical College, Tokorozawa, Saitama, Japan
⨯
Manabu Kinoshita,

Roles Funding acquisition, Methodology, Project administration

Affiliation Department of Immunology and Microbiology, National Defense Medical College, Tokorozawa, Saitama, Japan
⨯
Masami Ikarashi,

Roles Investigation, Methodology

Affiliation Department of Immunology and Microbiology, National Defense Medical College, Tokorozawa, Saitama, Japan
⨯
Makoto Makishima,

Roles Supervision

Affiliation Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, Itabashi, Tokyo, Japan

https://orcid.org/0000-0002-4630-905X

⨯
Shuhji Seki

Roles Conceptualization, Project administration, Supervision, Writing – original draft

Affiliation Department of Immunology and Microbiology, National Defense Medical College, Tokorozawa, Saitama, Japan
⨯

Contrasting functional responses of resident Kupffer cells and recruited liver macrophages to irradiation and liver X receptor stimulation

Takuya Ishikiriyama,
Hiroyuki Nakashima,
Kaori Endo-Umeda,
Masahiro Nakashima,
Seigo Ito,
Manabu Kinoshita,
Masami Ikarashi,
Makoto Makishima,
Shuhji Seki

Published: July 23, 2021
https://doi.org/10.1371/journal.pone.0254886

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