Aging increases senescence, calcium signaling, and extracellular matrix deposition in human airway smooth muscle

Sarah A. Wicher; Benjamin B. Roos; Jacob J. Teske; Yun Hua Fang; Christina Pabelick; Y. S. Prakash

doi:10.1371/journal.pone.0254710

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Open Access

Peer-reviewed

Research Article

Aging increases senescence, calcium signaling, and extracellular matrix deposition in human airway smooth muscle

Sarah A. Wicher,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, United States of America

https://orcid.org/0000-0002-0079-7924

⨯
Benjamin B. Roos,

Roles Data curation, Formal analysis, Writing – review & editing

Affiliation Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, United States of America
⨯
Jacob J. Teske,

Roles Data curation, Formal analysis, Software, Writing – review & editing

Affiliation Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, United States of America

https://orcid.org/0000-0002-3361-5859

⨯
Yun Hua Fang,

Roles Data curation, Formal analysis

Affiliation Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United States of America
⨯
Christina Pabelick,

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Writing – review & editing

Affiliations Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, United States of America, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United States of America

https://orcid.org/0000-0002-4632-2174

⨯
Y. S. Prakash

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Resources, Supervision, Writing – review & editing

* E-mail: Prakash.ys@mayo.edu

Affiliations Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, United States of America, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United States of America

https://orcid.org/0000-0002-2968-224X

⨯

Aging increases senescence, calcium signaling, and extracellular matrix deposition in human airway smooth muscle

Sarah A. Wicher,
Benjamin B. Roos,
Jacob J. Teske,
Yun Hua Fang,
Christina Pabelick,
Y. S. Prakash

Published: July 29, 2021
https://doi.org/10.1371/journal.pone.0254710

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Aging
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Elderly
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Senescence
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Geriatric care
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Histamine
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Collagens
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Gene expression
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Mitochondria
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