Quinazolin-derived myeloperoxidase inhibitor suppresses influenza A virus-induced reactive oxygen species, pro-inflammatory mediators and improves cell survival

• Juan A. De La Cruz ,

  Contributed equally to this work with: Juan A. De La Cruz, Thota Ganesh

  Roles Investigation, Methodology, Validation

  Affiliation Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

  ⨯
• Thota Ganesh ,

  Contributed equally to this work with: Juan A. De La Cruz, Thota Ganesh

  Roles Investigation, Methodology, Validation

  Affiliation Department of Pharmacology, Emory University, Atlanta, Georgia, United States of America

  ⨯
• Becky A. Diebold,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Department of Pathology, Emory University, Atlanta, Georgia, United States of America

  ⨯
• Weiping Cao,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

  ⨯
• Amelia Hofstetter,

  Roles Investigation, Methodology

  Affiliation Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

  ⨯
• Neetu Singh,

  Roles Investigation, Methodology

  Affiliation Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

  ⨯
• Amrita Kumar,

  Roles Investigation, Methodology

  Affiliation Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

  ⨯
• James McCoy,

  Roles Investigation, Methodology

  Affiliation Department of Pathology, Emory University, Atlanta, Georgia, United States of America

  ⨯
• Priya Ranjan,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

  ⨯
• Susan M. E. Smith,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Department of Pathology, Emory University, Atlanta, Georgia, United States of America

  ⨯
• Suryaprakash Sambhara,

  Roles Conceptualization, Data curation, Formal analysis, Resources

  Affiliation Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

  ⨯
• J. David Lambeth ,

  Roles Conceptualization, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: sgangappa@cdc.gov (SG); noxdoc@mac.com (JDL)

  Affiliation Department of Pathology, Emory University, Atlanta, Georgia, United States of America

  ⨯
• Shivaprakash Gangappa

  Roles Conceptualization, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: sgangappa@cdc.gov (SG); noxdoc@mac.com (JDL)

  Affiliation Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

  https://orcid.org/0000-0001-6217-9665

  ⨯