DNA methylation analyses identify an intronic ZDHHC6 locus associated with time to recurrent stroke in the Vitamin Intervention for Stroke Prevention (VISP) clinical trial

• Nicole M. Davis Armstrong,

  Roles Conceptualization, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Biology, East Carolina University, Greenville, NC, United States of America

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• Wei-Min Chen,

  Roles Data curation, Methodology, Writing – review & editing

  Affiliations Center for Public Health Genomics, University of Virginia, Charlottesville, VA, United States of America, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, United States of America

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• Fang-Chi Hsu,

  Roles Data curation, Formal analysis, Methodology, Writing – review & editing

  Affiliation Department of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, United States of America

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• Michael S. Brewer,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation Department of Biology, East Carolina University, Greenville, NC, United States of America

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• Natalia Cullell,

  Roles Formal analysis, Validation, Writing – review & editing

  Affiliations Stroke Pharmacogenomics and Genetics, Fundació Docència i Recerca Mútua Terrassa, Hospital Universitari Mútua de Terrassa, Terrassa, Barcelona, Spain, Stroke Pharmacogenomics and Genetics, Sant Pau Institute of Research, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain

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• Israel Fernández-Cadenas,

  Roles Validation, Writing – review & editing

  Affiliations Stroke Pharmacogenomics and Genetics, Fundació Docència i Recerca Mútua Terrassa, Hospital Universitari Mútua de Terrassa, Terrassa, Barcelona, Spain, Stroke Pharmacogenomics and Genetics, Sant Pau Institute of Research, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain

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• Stephen R. Williams,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliation Department of Neurology, University of Virginia, Charlottesville, VA, United States of America

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• Michèle M. Sale,

  Roles Conceptualization, Data curation, Funding acquisition, Resources

  Affiliations Center for Public Health Genomics, University of Virginia, Charlottesville, VA, United States of America, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, United States of America

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• Bradford B. Worrall,

  Roles Conceptualization, Funding acquisition, Methodology, Resources, Writing – review & editing

  Affiliations Department of Public Health Sciences, University of Virginia, Charlottesville, VA, United States of America, Department of Neurology, University of Virginia, Charlottesville, VA, United States of America

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• Keith L. Keene

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: keenek@ecu.edu

  Affiliations Department of Biology, East Carolina University, Greenville, NC, United States of America, Center for Health Disparities, Brody School of Medicine, East Carolina University, Greenville, NC, United States of America

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