Deficiency in Lyst function leads to accumulation of secreted proteases and reduced retinal adhesion

• Xiaojie Ji,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft

  Affiliations The Jackson Laboratory, Bar Harbor, ME, United States of America, Graduate School of Biomedical Science and Engineering, University of Maine, Orono, ME, United States of America

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• Lihong Zhao,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation The Jackson Laboratory, Bar Harbor, ME, United States of America

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• Ankita Umapathy,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Ophthalmology and Stein Eye Institute, University of California, Los Angeles, CA, United States of America

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• Bernard Fitzmaurice,

  Roles Methodology, Resources

  Affiliation The Jackson Laboratory, Bar Harbor, ME, United States of America

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• Jieping Wang,

  Roles Investigation, Resources

  Affiliation The Jackson Laboratory, Bar Harbor, ME, United States of America

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• David S. Williams,

  Roles Formal analysis, Funding acquisition, Writing – review & editing

  Affiliations Department of Ophthalmology and Stein Eye Institute, University of California, Los Angeles, CA, United States of America, Department of Neurobiology, David Geffen School of Medicine, UCLA, Los Angeles, CA, United States of America, Molecular Biology Institute, UCLA, Los Angeles, CA, United States of America, Brain Research Institute, UCLA, Los Angeles, CA, United States of America

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• Bo Chang,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliation The Jackson Laboratory, Bar Harbor, ME, United States of America

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• Jürgen K. Naggert ,

  Roles Conceptualization, Writing – review & editing

  * E-mail: Juergen.Naggert@jax.org (JKN); Patsy.Nishina@jax.org (PMN)

  Affiliation The Jackson Laboratory, Bar Harbor, ME, United States of America

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• Patsy M. Nishina

  Roles Conceptualization, Funding acquisition, Writing – review & editing

  * E-mail: Juergen.Naggert@jax.org (JKN); Patsy.Nishina@jax.org (PMN)

  Affiliation The Jackson Laboratory, Bar Harbor, ME, United States of America

  https://orcid.org/0000-0003-1640-5945

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