Identification of a distal RXFP1 gene enhancer with differential activity in fibrotic lung fibroblasts involving AP-1

• Ting-Yun Chen ,

  Contributed equally to this work with: Ting-Yun Chen, Xiaoyun Li

  Roles Conceptualization, Data curation, Formal analysis, Writing – original draft, Writing – review & editing

  Affiliations Division of Pulmonary, Allergy and Critical Care Medicine and The Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, University of Pittsburgh, Pittsburgh, PA, United States of America, Institute of Allied Health Sciences, National Cheng Kung University, Tainan, Taiwan

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• Xiaoyun Li ,

  Contributed equally to this work with: Ting-Yun Chen, Xiaoyun Li

  Roles Data curation, Formal analysis, Methodology, Writing – original draft

  Affiliation Division of Pulmonary, Allergy and Critical Care Medicine and The Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, University of Pittsburgh, Pittsburgh, PA, United States of America

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• Gillian C. Goobie,

  Roles Formal analysis, Writing – review & editing

  Affiliations Division of Pulmonary, Allergy and Critical Care Medicine and The Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, University of Pittsburgh, Pittsburgh, PA, United States of America, Department of Medicine, Clinician Investigator Program, University of British Columbia, Vancouver, B.C., Canada, Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, United States of America

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• Ching-Hsia Hung,

  Roles Supervision, Writing – review & editing

  Affiliation Institute of Allied Health Sciences, National Cheng Kung University, Tainan, Taiwan

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• Tin-Kan Hung,

  Roles Formal analysis, Writing – review & editing

  Affiliation Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, United States of America

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• Kyle Hamilton,

  Roles Data curation, Writing – review & editing

  Affiliation Division of Pulmonary, Allergy and Critical Care Medicine and The Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, University of Pittsburgh, Pittsburgh, PA, United States of America

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• Harinath Bahudhanapati,

  Roles Methodology, Writing – review & editing

  Affiliation Division of Pulmonary, Allergy and Critical Care Medicine and The Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, University of Pittsburgh, Pittsburgh, PA, United States of America

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• Jiangning Tan,

  Roles Methodology, Writing – review & editing

  Affiliation Division of Pulmonary, Allergy and Critical Care Medicine and The Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, University of Pittsburgh, Pittsburgh, PA, United States of America

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• Daniel J. Kass,

  Roles Investigation, Writing – review & editing

  Affiliation Division of Pulmonary, Allergy and Critical Care Medicine and The Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, University of Pittsburgh, Pittsburgh, PA, United States of America

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• Yingze Zhang

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: zhanyx@upmc.edu

  Affiliations Division of Pulmonary, Allergy and Critical Care Medicine and The Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, University of Pittsburgh, Pittsburgh, PA, United States of America, Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, United States of America, Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, United States of America

  https://orcid.org/0000-0001-6947-2901

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